FB2026_02 , released June 18, 2026
Allele: Dmel\grkUAS.cBa
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General Information
Symbol
Dmel\grkUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Bokel
FlyBase ID
FBal0193431
Feature type
allele
Associated gene
Dmel\grk
Associated Insertion(s)
Carried in Construct
P{UAS-grk}
Key Links
Transgenic product class
wild_type
(Bokel et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bokel et al., 2006)
Mutagen
in vitro construct
(Bokel et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-grk}
Cytology
Description

UAS regulatory sequences drive expression of grk coding sequences.

(Bokel et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
grk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females expressing grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 produce eggs where operculum is present along the entire dorsoventral axis (30% of eggs). The anterior-posterior width of the operculum is not altered in these eggs.

      (Shravage et al., 2007)

      Expression of grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 results in egg chambers that are severely dorsalised, despite maintaining dorsal-ventral polarity. The operculum is expanded, while the dorsal appendages, that are normally specified at more lateral positions, are shifted to the ventral side of the egg.

      (Bokel et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of dppScer\UAS.cSa and grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 and Scer\GAL4GR1 results in eggs with a large anterior operculum followed by a symmetrical band of dorsal appendage material.

      Co-expression of dppScer\UAS.cSa and grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 and Scer\GAL4CY2 results in eggs with an expansion of the operculum at the expense of dorsal appendage material.

      (Shravage et al., 2007)

      Expression of grkScer\UAS.cBa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in a cni1/Df(2L)H60-3 background results in eggs with variable amounts of dorsal appendage material. The eggs lack dorsal-ventral and frequently even anteroposterior polarity (in 30% of cases), illustrated by a patchy induction of the dorsal appendage material around the entire egg circumference and the presence of a posterior micropyle.

      (Bokel et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      grkScer\UAS.cBa
      grkUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Bokel
      Secondary FlyBase IDs
        References (3)