FlyBase Allele Report: Dmel\path[GS13857]

General Information

Symbol

Dmel\path^GS13857

Species

D. melanogaster

Name

FlyBase ID

FBal0193815

Feature type

allele

Associated gene

Dmel\path

Associated Insertion(s)

P{GSV6}path^GS13857

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Goberdhan et al., 2005)

Progenitor genotype

Associated Insertion(s)

P{GSV6}path^GS13857

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:9,505,347..9,505,347

(Goberdhan et al., 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number, with Scer\GAL4^en-e16E

(Goberdhan et al., 2005)

increased cell size, with Scer\GAL4^en-e16E

(Goberdhan et al., 2005)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

eye (with path^GS11111), with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

ommatidium, with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

ommatidium (with path^GS11111), with Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

wing, with Scer\GAL4^Bx-MS1096

(Goberdhan et al., 2005)

wing, with Scer\GAL4^en-e16E

(Goberdhan et al., 2005)

Detailed Description

Statement

Reference

Overexpression of path^GS13857, under the control of Scer\GAL4^GMR.PF, increases both ommatidial and overall eye size.

When path^GS11111 and path^GS13857 are coexpressed under the control of Scer\GAL4^GMR.PF the resulting eyes bulge more from the head capsule and the ommatidial array is mildly disorganised.

path^GS13857 overexpression in the posterior wing compartment of the wing, driven by Scer\GAL4^en-e16E, produces an increase in cell size, even though wing area is reduced. Likewise, expression of path^GS13857 in the wing, driven by Scer\GAL4^Bx-MS1096, leads to a reduction in wing size.

(Goberdhan et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

path^GS13857/Scer\GAL4^Bx-MS1096 is an enhancer of decreased cell number phenotype of Scer\GAL4^Bx-MS1096, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, path^GS13857 has eye phenotype, enhanceable by mTor^{WT.UAS.Tag:FLAG}/Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, foxo^GS9928, path^GS13857 has ommatidium phenotype, suppressible by Akt^UAS.cSa, Scer\GAL4^GMR.PF

(Goberdhan et al., 2005)

Enhancer of

Statement

Reference

path^GS13857/Scer\GAL4^Bx-MS1096 is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, mTor^{WT.UAS.Tag:FLAG}

(Goberdhan et al., 2005)

path^GS13857/Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, foxo^GS9928

(Goberdhan et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

When cooverexpressed with path^GS13857, under the control of Scer\GAL4^GMR.PF, Tor^{WT.Scer\UAS.T:Zzzz\FLAG} significantly enhances the overgrowth phenotype induced by path^GS13857 alone.

path^GS13857 significantly enhances the reduced wing phenotype produced by overexpressing Tor^{WT.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^Bx-MS1096.

Co-expression of foxo^GS9928 with path^GS13857, driven by Scer\GAL4^GMR.PF, enhances the foxo^GS9928 reduced eye phenotype , an effect completely suppressed by Akt1^Scer\UAS.cSa co-expression.

(Goberdhan et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

204997

y¹ w^67c23; P{GSV6}path^GS13857/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

path^GS13857

(Ogmundsdóttir et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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