FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\pydBG02748
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General Information
Symbol
Dmel\pydBG02748
Species
D. melanogaster
Name
FlyBase ID
FBal0194118
Feature type
allele
Associated gene
Dmel\pyd
Associated Insertion(s)
P{GT1}pydBG02748
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Jung et al., 2006)
Mutagen
P-element activity
(Jung et al., 2006)
Progenitor genotype
Associated Insertion(s)
P{GT1}pydBG02748
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GT1}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pydBG02748 embryos display defects in tracheal development including dorsal branch fusion problems, ectopic terminal cells, a lack of fusion cells, and ganglionic branch outgrowth defects. The dorsal branch phenotype is not fully penetrant; 2% of embryos show wild-type tracheal systems, 17% show defects in 1 metamere, 43% show defects in 2-4 metameres and 40% show defects in >5 metameres. Fusion defects are occasionally observed in the lateral trunk, although the penetrance of this is lower than for the dorsal branch.

      pydBG02748/Df(3R)p-XT103 transheterozygotes show the same tracheal phenotypes as pydBG02748 homozygotes.

      The dorsal branches of pydBG02748 embryos show large loops of intercellular adherens junctions, indicating that cell intercalation is not complete. These intercalation defects are not fully penetrant. Ganglionic branches also show defective cell intercalation.

      (Jung et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      pydBG02748 is partially rescued by Scer\GAL4btl.PS/pydUAS.cJa

      (Jung et al., 2006)

      pydBG02748 is partially rescued by pydUAS.EGFP/Scer\GAL4btl.PS

      (Jung et al., 2006)
      Comments

      Expression of either pydScer\UAS.T:Avic\GFP-EGFP or pydScer\UAS.cJa under the control of Scer\GAL4btl.PS partially rescues the tracheal phenotype of pydBG02748 embryos. pydBG02748>pydScer\UAS.T:Avic\GFP-EGFP expression provides full rescue of the tracheal cell intercalation phenotype.

      (Jung et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pydBG02748
      (Goossens et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)