FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PINK1UAS.Tag:FLAG
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General Information
Symbol
Hsap\PINK1UAS.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0196253
Feature type
allele
Associated gene
Hsap\PINK1
Associated Insertion(s)
Carried in Construct
P{UAS-hPINK1.FLAG}
Also Known As
UAS-hPINK1
Key Links
Transgenic product class
cDNA
(Wang et al., 2006)
wild_type
(Wang et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Wang et al., 2006)
wild_type
(Wang et al., 2006)
Mutagen
in vitro construct
(Wang et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-hPINK1.FLAG}
Cytology
Description

UASt sequences drive expression of a cDNA encoding the entire coding sequence of wild type Hsap\PINK1 with a C-terminal Tag:FLAG tag.

(Wang et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\PINK1
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease 6
      modeled by Pink1B9
      (Liao et al., 2024)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies overexpressing Hsap\PINK1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4da.G32 show reduced sensitivity to treatment with paraquat or H2O2 but not 2-mercaptoethanol.

      (Wang et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\PINK1Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU rescues the defects in mobilisation of the reserve pool of synaptic vesicles which are seen in Pink1B9 mutant larvae.

      (Morais et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\PINK1Scer\UAS.T:Zzzz\FLAG
      Hsap\PINK1UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (4)