FlyBase Allele Report: Dmel\Smox[UAS.cZa]

General Information

Symbol

Dmel\Smox^UAS.cZa

Species

D. melanogaster

Name

FlyBase ID

FBal0196304

Feature type

allele

Associated gene

Dmel\Smox

Associated Insertion(s)

Carried in Construct

P{UAS-dSmad2.Z}

Also Known As

UAS-dSmad2, UAS.dSmad2

Key Links

Transgenic product class

wild_type

(Zheng et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zheng et al., 2003)

Mutagen

in vitro construct

(Zheng et al., 2003, Marquez et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-dSmad2.Z}

Cytology

Description

A 3.1kb SalI/NotI fragment of Smox is driven by UASt sequences.

(Zheng et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Smox

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates generalized dystonia

modeled by Hsap\TOR1A^ΔE.UAS

(Koh et al., 2004)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^A9

(Marquez et al., 2001)

Phenotype Manifest In

wing, with Scer\GAL4^A9

(Marquez et al., 2001)

wing, with Scer\GAL4^nub-AC-62

(Barrio et al., 2007)

Detailed Description

Statement

Reference

Expression of Smox^Scer\UAS.cZa using Scer\GAL4^salm-459.2 has no severe effects on wing growth or patterning.

Expression of Smox^Scer\UAS.cZa using Scer\GAL4^nub-AC-62 causes a weak increase in wing size.

(Barrio et al., 2007)

When expression is driven by Scer\GAL4^A9, wings are enlarged by approximately 22%.

(Marquez et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Smox^UAS.cZa, Scer\GAL4^elav-C155 is a suppressor of abnormal locomotor behavior | heat sensitive phenotype of Hsap\TOR1A^ΔE.UAS, Scer\GAL4^elav-C155

(Koh et al., 2004)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9/Smox^UAS.cZa is a non-suppressor of visible phenotype of Scer\GAL4^A9, Snoo^UAS.cTa

(Takaesu et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

Smox^UAS.cZa, Scer\GAL4^elav-C155 is a suppressor of NMJ bouton phenotype of Hsap\TOR1A^ΔE.UAS, Scer\GAL4^elav-C155

(Koh et al., 2004)

NOT Suppressor of

Statement

Reference

Scer\GAL4^A9/Smox^UAS.cZa is a non-suppressor of wing phenotype of Scer\GAL4^A9, Snoo^UAS.cTa

(Takaesu et al., 2006)

Scer\GAL4^A9/Smox^UAS.cZa is a non-suppressor of wing vein phenotype of Scer\GAL4^A9, Snoo^UAS.cTa

(Takaesu et al., 2006)

Other

Statement

Reference

Scer\GAL4^nub-AC-62, Smox^UAS.cZa, Snoo^M67 has wing phenotype

(Barrio et al., 2007)

Scer\GAL4^nub-AC-62, Smox^UAS.cZa, Snoo^M67 has wing vein phenotype

(Barrio et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Snoo^M67 and Smox^Scer\UAS.cZa using Scer\GAL4^nub-AC-62 generates very small wings without veins.

(Barrio et al., 2007)

Co-expression of Smox^Scer\UAS.cZa has little effect on the wing phenotypes caused by expression of Snoo^Scer\UAS.cTa under the control of Scer\GAL4^A9.

(Takaesu et al., 2006)

Xenogenetic Interactions

Statement

Reference

Expression of Smox^Scer\UAS.cZa in flies expressing Hsap\TOR1A^ΔE.Scer\UAS under the control of Scer\GAL4^elav-C155 substantially rescues the locomotor defects seen when Hsap\TOR1A^ΔE.Scer\UAS is expressed alone in flies subjected to 38[o]C. Larval synaptic bouton morphology is also rescued in these animals.

(Koh et al., 2004)

Complementation and Rescue Data

Rescues

Scer\GAL4^arm.PS/Smox^UAS.cZa rescues Smox^MB388

(Zheng et al., 2003)

Scer\GAL4^Tab2-201Y/Smox^UAS.cZa rescues Smox^MB388

(Zheng et al., 2003)

Comments

The addition of Smox^Scer\UAS.cZa when driven by Scer\GAL4^Tab2-201Y rescues the γ neuron projection phenotype seen in single cell clones of Smox^MB388. The addition of Smox^Scer\UAS.cZa when driven by Scer\GAL4^arm.PS rescues the lethality of Smox^MB388.

(Zheng et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Smox^Scer\UAS.cAa

Smox^Scer\UAS.cZa

Smox^UAS.cZa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Anonymous

(Marquez et al., 2001)

Secondary FlyBase IDs

FBal0144564
FBal0123049

References (6)

Report Sections

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