FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\IKKεUAS.cKa
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General Information
Symbol
Dmel\IKKεUAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kuranaga
FlyBase ID
FBal0196640
Feature type
allele
Associated gene
Dmel\IKKε
Associated Insertion(s)
Carried in Construct
P{UAS-IKKε.K}
Also Known As
UAS-ik2
Key Links
Transgenic product class
cDNA
(Kuranaga et al., 2006)
wild_type
(Kuranaga et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kuranaga et al., 2006)
wild_type
(Kuranaga et al., 2006)
Mutagen
in vitro construct
(Kuranaga et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-IKKε.K}
Cytology
Description

UASt regulatory sequences drive expression of full-length IKKε (derived from the GM07508 cDNA clone).

(Kuranaga et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
IKKε
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At non-permissive temperatures (29[o]C) in the presence of Scer\GAL80ts.αTub84B, Scer\GAL4ppk.PG overexpression of IKKεScer\UAS.cKa leads to dendrite severing and apoptosis in larval neurons (no phenotype at 25[o]C).

      (Lin et al., 2015)

      Larvae carrying ik2Scer\UAS.cKa and Scer\GAL4ppk.PG in the presence of Scer\GAL80ts.αTub84B show normal ddaC neuron morphology at 25[o]C (the permissive temperature for Scer\GAL80ts.αTub84B, which inhibits Scer\GAL4). However, upon shifting to 29[o]C (to relieve the inhibition of Scer\GAL80ts.αTub84B on Scer\GAL4ppk.PG), precocious dendrite severing is triggered in the proximal dendrites of some larval ddaC neurons. In addition, some cell death is seen in these neurons, characterised by the blebbing of dendrites and axons.

      (Lee et al., 2009)

      Expression of ik2Scer\UAS.T:Hsap\MYC in flies, under the control of Scer\GAL4GMR.PF, causes a severe eye-ablation phenotype due to cell death in the eye.

      Expression of ik2Scer\UAS.cKa, under the control of Scer\GAL4sca-P309, results in the presence of extra macrochaetae on the adult notum and extra sensory organ precursors in the wing disc.

      (Kuranaga et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      spn-F2/spn-F2 partially suppresses the dendrite severing and apoptosis seen in larvae with IKKεScer\UAS.cKa overexpressed by Scer\GAL4ppk.PG in combination with Scer\GAL80ts.αTub84B at non-permissive (29[o]C) temperatures.

      (Lin et al., 2015)

      Expression of NcC318G.Scer\UAS partially suppresses the eye ablation phenotype seen in Scer\GAL4GMR.PF>ik2Scer\UAS.cKa flies.

      (Kuranaga et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      IKKεScer\UAS.cKa
      IKKεUAS.cKa
      ik2Scer\UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kuranaga
      Secondary FlyBase IDs
        References (3)