FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ppk11MB02012
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General Information
Symbol
Dmel\ppk11MB02012
Species
D. melanogaster
Name
FlyBase ID
FBal0196959
Feature type
allele
Associated gene
Dmel\ppk11
Associated Insertion(s)
Mi{ET1}ppk11MB02012
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}ppk11MB02012
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  nervous system disease
        modeled by AtpαCJ5
        (Talsma et al., 2014)
        modeled by AtpαDTS1
        (Talsma et al., 2014)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant third instar larvae show no significant increase in quantal content at the neuromuscular junction in the presence of the glutamate receptor antagonist philanthotoxin-433 (10μM), indicating a defect in synaptic homeostasis. In the absence of philanthotoxin-433, the mutant larvae show no significant change in evoked excitatory postsynaptic potential (EPSP) amplitude, miniature mEPSP amplitude or quantal content compared to controls.

        (Younger et al., 2013)

        Mutant flies show normal responses to both low salt (50mM NaCl) and high salt (500mM NaCl) in a two-way choice test. The electrophysiological response of the L4 sensilla to 50mM NaCl and the electrophysiological response of the gustatory receptor neurons in the S6 sensilla to 500mM NaCl is normal in these flies.

        (Zhang et al., 2013)

        ppk11MB02012 flies exhibit a wild-type water-elicited proboscis extension reflex.

        (Chen et al., 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Precise excision of the insertion reverts the mutant neuromuscular junction phenotype.

        (Younger et al., 2013)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        ppk11MB02012
        (Bellen, 2007.5.7)
        ppk11MB
        (Zhang et al., 2013)
        ppk11Mi
        (Younger et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)