FlyBase Allele Report: Dmel\Gbp2[GD4931]

General Information

Symbol

Dmel\Gbp2^GD4931

Species

D. melanogaster

Name

FlyBase ID

FBal0199412

Feature type

allele

Associated gene

Dmel\Gbp2

Associated Insertion(s)

Carried in Construct

P{GD4931}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4931}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4931

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Gbp2^GD4931 expression driven by Scer\GAL4^C7 induces significant decreases in male and female body size (body weight measured at pharate adult stage), significantly slows down larval growth rate and significantly increases the duration of the third instar larval stage.

Gbp2^GD4931 expression driven by Scer\GAL4^ppl.PP induces significant decreases in male and female body size (body weight measured at pharate adult stage), reduces larval growth rate and increases the duration of the third instar larval stage.

(Koyama and Mirth, 2016)

Adults expressing CG11395^GD4931 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4931

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Gbp2^GD4931, Scer\GAL4^C7 has decreased body size | pharate adult stage phenotype, enhanceable by Gbp1^KK110262, Scer\GAL4^C7

(Koyama and Mirth, 2016)

Gbp2^GD4931, Scer\GAL4^ppl.PP has abnormal developmental rate | larval stage phenotype, enhanceable by Gbp1^KK110262, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Gbp2^GD4931, Scer\GAL4^ppl.PP has decreased body size | pharate adult stage phenotype, enhanceable by Gbp1^KK110262, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Enhancer of

Statement

Reference

Gbp2^GD4931, Scer\GAL4^C7 is an enhancer of decreased body size | pharate adult stage phenotype of Gbp1^KK110262, Scer\GAL4^C7

(Koyama and Mirth, 2016)

Gbp2^GD4931, Scer\GAL4^ppl.PP is an enhancer of decreased body size | pharate adult stage phenotype of Gbp1^KK110262, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Gbp2^GD4931, Scer\GAL4^ppl.PP is an enhancer of abnormal developmental rate | larval stage phenotype of Gbp1^KK110262, Scer\GAL4^ppl.PP

(Koyama and Mirth, 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Gbp1^KK110262 enhances decreased body size seen in male and female flies with Gbp2^GD4931 driven by Scer\GAL4^C7.

Co-expression of Gbp1^KK110262 enhances the male and female fly decreased body size, along with the decreased larval growth rate and the increase in duration of the third instar stage seen in larvae with Gbp2^GD4931 driven by Scer\GAL4^ppl.PP.

(Koyama and Mirth, 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v16696

w¹¹¹⁸; P{GD4931}v16696

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4931

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG11395^GD4931

Gbp2^GD4931

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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