FlyBase Allele Report: Dmel\Sting[GD1905]

General Information

Symbol

Dmel\Sting^GD1905

Species

D. melanogaster

Name

FlyBase ID

FBal0201587

Feature type

allele

Associated gene

Dmel\Sting

Associated Insertion(s)

Carried in Construct

P{GD1905}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1905}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1905

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^Hml.PG

(Segrist et al., 2024)

abnormal immune response, with Scer\GAL4^how-24B

(Segrist et al., 2024)

abnormal immune response, with Scer\GAL4^yolk

(Segrist et al., 2024)

abnormal immune response | adult stage, with Scer\GAL4^Act5C.PI

(Segrist et al., 2021, Martin et al., 2018)

abnormal immune response | adult stage, with Scer\GAL4^elav-C155

(Liu et al., 2018)

abnormal immune response | adult stage, with Scer\GAL4^NP0001

(Segrist et al., 2021)

abnormal immune response | adult stage, with Scer\GAL4^repo

(Liu et al., 2018)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^da.G32

(Lee et al., 2020)

increased mortality | adult stage | conditional, with Scer\GAL4^yolk

(Segrist et al., 2024)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Sting^GD1905 under the control of Scer\GAL4^NP0001 leads to adults orally or systemically infected with Drosophila C Virus (DCV),as well as adults orally infected with Sindbis virus (SINV) showing increased viral load compared to controls.

Expression under the control of Scer\GAL4^Act5C.PI leads to adults systemically infected with DCV, but not SINV, showing increased viral load compared to controls.

(Segrist et al., 2021)

Expression of Sting^GD1905 under the control of Scer\GAL4^da.G32 leads to a modest but significant decrease in climbing ability (negative geotaxis) in older (20 days old) flies, but not in young (2 days old) flies, as compared to controls.

(Lee et al., 2020)

Adults expressing Sting^GD1905 under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^repo infected with ZIKV present an increased viral load in the head, as compared to infected controls.

(Liu et al., 2018)

The expression of Sting^GD1905 under the control of Scer\GAL4^Act5C.PI leads to significantly increased bacterial load and mortality upon infection of adults with Listeria monocytogenes, as compared to controls.

(Martin et al., 2018)

Adults expressing CG1667^GD1905 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1905

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of visible | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of visible | adult stage phenotype of park²⁵

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of visible | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of visible | adult stage phenotype of park²⁵

(Lee et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of adult thorax phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of adult thorax phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-enhancer of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of adult thorax phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of adult thorax phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Scer\GAL4^da.G32/Sting^GD1905 is a non-suppressor of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Sting^GD1905 under the control of Scer\GAL4^da.G32 does not modify the impaired climbing ability, thoracic indentations, or disrupted tissue or mitochondrial integrity in the flight muscles phenotype of young park²⁵ and Pink1^B9 mutants.

(Lee et al., 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v4031

w¹¹¹⁸; P{GD1905}v4031

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1905

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG1667^GD1905

Sting^GD1905

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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