FlyBase Allele Report: Dmel\CG2004[GD9700]

General Information

Symbol

Dmel\CG2004^GD9700

Species

D. melanogaster

Name

FlyBase ID

FBal0202222

Feature type

allele

Associated gene

Dmel\CG2004

Associated Insertion(s)

Carried in Construct

P{GD9700}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9700}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9700

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates retinitis pigmentosa

modeled by ninaE^G69D.UAS

(Chow et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal, with Scer\GAL4^Tub.PU

(Scanlan et al., 2020)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of CG2004^GD9700 under the control of Scer\GAL4^GMR.PF has no effect on the adult eye morphology.

(Chow et al., 2016)

Adults expressing CG2004^GD9700 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9700

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CG2004^GD9700, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

CG2004^GD9700, Scer\GAL4^GMR.PF is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

CG2004^GD9700, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, ninaE^G69D.UAS

(Chow et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The small eye phenotype characteristic for adult flies expressing ninaE^{G69D.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced further by co-expression of CG2004^GD9700.

(Chow et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v25389