FlyBase Allele Report: Dmel\Prp38[GD10048]

General Information

Symbol

Dmel\Prp38^GD10048

Species

D. melanogaster

Name

FlyBase ID

FBal0202556

Feature type

allele

Associated gene

Dmel\Prp38

Associated Insertion(s)

Carried in Construct

P{GD10048}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD10048}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD10048

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

(Andersen and Tapon, 2008)

wing pouch | somatic clone, with Scer\GAL4^Act5C.PP

(Andersen and Tapon, 2008)

Detailed Description

Statement

Reference

The expression of Prp38^GD10048 under the control of Scer\GAL4^insc-Mz1407 does not lead to any obvious changes in type II neuroblast lineages.

(Abramczuk et al., 2017)

Adults expressing Prp38^GD10048 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in early pupal lethality or undefined lethality.

(Schnorrer et al., 2010)

Homozygous clones in the wing disc that are expressing Prp38^GD10048 under the control of Scer\GAL4^Act5C.PP are markedly smaller than control clones. Apoptosis is seen in the wing pouch in these mutant clones.

(Andersen and Tapon, 2008)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development