FlyBase Allele Report: Dmel\kibra[GD7772]

General Information

Symbol

Dmel\kibra^GD7772

Species

D. melanogaster

Name

FlyBase ID

FBal0203764

Feature type

allele

Associated gene

Dmel\kibra

Associated Insertion(s)

Carried in Construct

P{GD7772}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD7772}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7772

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Rett syndrome

modeled by Hsap\MECP2^UAS.FL

(Williams et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body color, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

lethal | pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

visible, with Scer\GAL4^GMR.PFa, Scer\GAL4^ey.200.Exel

(Genevet et al., 2010)

visible, with Scer\GAL4^GMR.PU

(Genevet et al., 2010)

visible, with Scer\GAL4^hh.PU

(Genevet et al., 2010)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PFa, Scer\GAL4^ey.200.Exel

(Genevet et al., 2010)

eye, with Scer\GAL4^GMR.PU

(Genevet et al., 2010)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

wing blade posterior compartment, with Scer\GAL4^hh.PU

(Genevet et al., 2010)

Detailed Description

Statement

Reference

Expression of kibra^GD7772 driven by Scer\GAL4^futsch-C380 (along with Scer\GAL80^ChAT.3.3P) does not significantly affect dendritic branch length or number in MN5 motoneurons, though there are subtle changes in branch patterning (fewer branches closer to the primary neurite).

(Williams et al., 2016)

Expression of kibra^GD7772 under the control of Scer\GAL4^GMR.PF results in eye overgrowth.

(Genevet et al., 2010)

Expression of kibra^GD7772 under the control of Scer\GAL4^hh.PU results in overgrowth of the posterior wing compartment.

Expression of kibra^GD7772 under the simultaneous control of both Scer\GAL4^GMR.PFa and Scer\GAL4^ey.200.Exel results in adults with increased eye size compared to controls. The retinas contain an excess of interommatidial cells.

(Genevet et al., 2010)

Adults expressing kibra^GD7772 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality or semi-lethality at the pupal stage, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 100% of the Scer\GAL4^pnr-MD237 expression domain.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7772

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL80^ChAT.3.3P, kibra^GD7772, Scer\GAL4^futsch-C380 is a suppressor of abnormal neuroanatomy phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P

(Williams et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL80^ChAT.3.3P, kibra^GD7772, Scer\GAL4^futsch-C380 is a suppressor of indirect flight muscle motor neuron DLMN5 phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P

(Williams et al., 2016)

Scer\GAL80^ChAT.3.3P, kibra^GD7772, Scer\GAL4^futsch-C380 is a suppressor of dendrite phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^futsch-C380, Scer\GAL80^ChAT.3.3P

(Williams et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of kibra^GD7772 significantly suppresses the decreases in dendritic branch length (fully) and number (partially) in MN5 motoneurons with expression of Hsap\MECP2^Scer\UAS.FL driven by Scer\GAL4^futsch-C380 (along with Scer\GAL80^ChAT.3.3P).

(Williams et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v31993

w¹¹¹⁸ P{GD7772}v31993

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7772

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG33967^GD7772

kibra^GD7772

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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