FB2026_02 , released June 18, 2026
Allele: Dmel\CG7379GD12222
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General Information
Symbol
Dmel\CG7379GD12222
Species
D. melanogaster
Name
FlyBase ID
FBal0205452
Feature type
allele
Associated gene
Dmel\CG7379
Associated Insertion(s)
Carried in Construct
P{GD12222}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD12222}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD12222
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  carcinoma
      CEA
      (Rusu et al., 2021)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by l(2)gl4
      (Rusu et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Clones in the pupal dorsal thorax epithelium that express CG7379GD12222 under the control of Scer\GAL4pnr.PU show some delamination/invasion (i.e. multilayered polarized epithelial cells beneath the epithelial sheet), as well as defective adherens and septate junctions and abnormal morphology of cell protrusions; pre-invasive cells show decreased apoptosis as compared to controls.

      (Rusu et al., 2021)

      Adults expressing CG7379GD12222 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in a weak flyer phenotype.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 0% or 70-80% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 0% or 40-50% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      NOT suppressed by
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In pupal dorsal thorax epithelium clones that are homozygous for l(2)gl4 and simultaneously express show CG7379GD12222 under the control of Scer\GAL4pnr.PU, pre-invasive cells show increased apoptosis.

      (Rusu et al., 2021)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CG7379GD12222
      Name Synonyms
      Secondary FlyBase IDs
        References (9)