FlyBase Allele Report: Dmel\Gpdh1[GD14102]

General Information

Symbol

Dmel\Gpdh1^GD14102

Species

D. melanogaster

Name

FlyBase ID

FBal0207141

Feature type

allele

Associated gene

Dmel\Gpdh1

Associated Insertion(s)

Carried in Construct

P{GD14102}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14102}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14102

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by brat^HMS01121

(Hussain et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

flightless, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

lethal, with Scer\GAL4^Act5C.PU

(Dietzl et al., 2007)

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in flightless flies or defects in locomotion.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in morphologically wild-type myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the adult indirect flight muscles.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14102

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Gpdh1^GD14102, Scer\GAL4^Act5C.PI is a suppressor of neoplasia phenotype of Scer\GAL4^Act5C.PI, brat^HMS01121

(Hussain et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Gpdh1^GD14102, Scer\GAL4^Act5C.PI is a suppressor of larval brain phenotype of Scer\GAL4^Act5C.PI, brat^HMS01121

(Hussain et al., 2017)

Other

Statement

Reference

Dcr-2^UAS.cDa, Gpdh1^GD14102, Scer\GAL4^GMR.PF, Scer\GAL4^ey.PH has eye phenotype

(Dietzl et al., 2007)

Dcr-2^UAS.cDa, Gpdh1^GD14102, Scer\GAL4^pnr-MD237 has scutellum phenotype

(Dietzl et al., 2007)

Dcr-2^UAS.cDa, Gpdh1^GD14102, Scer\GAL4^pnr-MD237 has thorax phenotype

(Dietzl et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The tumor growth rate of larval brain explants expressing brat^HMS01121 under the control of Scer\GAL4^Act5C.PI is suppressed upon co-expression of Gpdh^GD14102.

(Hussain et al., 2017)

Coexpression of Gpdh^GD14102 with Dcr-2^Scer\UAS.cDa, under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.PF, results in small, rough, glazed eyes that are not seen when Gpdh^GD14102 alone is expressed. Coexpression of these transgenes under the control of Scer\GAL4^pnr-MD237 results in thorax closure defects and a fused scutellum.

(Dietzl et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v29013

w¹¹¹⁸; P{GD14102}v29013

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14102

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Gpdh1^GD14102

Gpdh^GD14102

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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