FlyBase Allele Report: Dmel\LIMK1[GD9586]

General Information

Symbol

Dmel\LIMK1^GD9586

Species

D. melanogaster

Name

FlyBase ID

FBal0207470

Feature type

allele

Associated gene

Dmel\LIMK1

Associated Insertion(s)

Carried in Construct

P{GD9586}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9586}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9586

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Al-Ramahi et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing LIMK1^GD9586 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9586

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

LIMK1^GD9586, Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of abnormal developmental rate | somatic clone | larval stage phenotype of Raf^UAS.F179, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

LIMK1^GD9586, Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of eye-antennal disc | somatic clone | third instar larval stage phenotype of Raf^UAS.F179, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

LIMK1^GD9586, Scer\GAL4^Tub.PU is a non-suppressor | somatic clone of eye photoreceptor cell | somatic clone | third instar larval stage phenotype of Raf^UAS.F179, RhoGEF2^RE.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of LIMK1^GD9586 fails to suppress the reduction of differentiation seen in eye-antennal disc clones expressing both RhoGEF2^RE.Scer\UAS and Raf^{Scer\UAS.F179} under the control of Scer\GAL4^tub.PU, and also fails to suppress the developmental delay shown by larvae containing these clones.

(Khoo et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v25343