FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ogdh1GD4760
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General Information
Symbol
Dmel\Ogdh1GD4760
Species
D. melanogaster
Name
FlyBase ID
FBal0207721
Feature type
allele
Associated gene
Dmel\Ogdh1
Associated Insertion(s)
Carried in Construct
P{GD4760}
Also Known As
dOgdh RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD4760}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD4760
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  oxoglutarate dehydrogenase deficiency
      is ameliorated by Ogdh1UAS.Tag:FLAG
      (Yap et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      A neurodegenerative disorder has been ascribed to a mutation in the OGDH gene (a human ortholog of Nc73EF) in a patient. Mutations in three known disease-related genes have also been identified in this patient but their known clinical symptoms do not match the phenotype of the patient.

      (Yoon et al., 2017)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of OgdhGD4760 under the control of Scer\GAL4nSyb.PS leads to a progressive decrease in adult climbing ability.

      (Yap et al., 2021)

      Expression of Nc73EFGD4760 under the control of Scer\GAL4ninaE.PU leads to age-progressive loss of synaptic transmission in photoreceptor cells characterized by loss of on- and off-transients in electroretinogram readings compared to controls.

      (Yoon et al., 2017)

      Adults expressing Nc73EFGD4760 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

      (Schnorrer et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 60-70% of the Scer\GAL4pnr-MD237 expression domain.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 50-60% of the Scer\GAL4pnr-MD237-expressing area of the notum.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The loss of synaptic transmission in photoreceptor cells characterized by loss of on- and off-transients in electroretinogram readings observed in aged adult flies expressing Nc73EFGD4760 under the control of Scer\GAL4ninaE.PU is rescued by co-expression of either Hsap\OGDHLScer\UAS.cYa or Hsap\OGDHScer\UAS.cYa but not Hsap\OGDHLS778L.Scer\UAS or Hsap\OGDHS791L.Scer\UAS.

      (Yoon et al., 2017)
      Complementation and Rescue Data
      Rescued by

      Ogdh1GD4760 is rescued by Ogdh1UAS.Tag:FLAG/Scer\GAL4nSyb.PS

      (Yap et al., 2021)

      Ogdh1GD4760 is rescued by Scer\GAL4ninaE.PU/Ogdh1UAS.Tag:FLAG

      (Yoon et al., 2017)
      Not rescued by

      Ogdh1GD4760 is not rescued by Scer\GAL4nSyb.PS/Ogdh1N324S.UAS.Tag:FLAG

      (Yap et al., 2021)

      Ogdh1GD4760 is not rescued by Scer\GAL4ninaE.PU/Ogdh1S793L.UAS.Tag:FLAG

      (Yoon et al., 2017)
      Comments

      Co-expression of Nc73EFS793L.Scer\UAS.T:Zzzz\FLAG but not Nc73EFS793L.Scer\UAS.T:Zzzz\FLAG significantly improves the loss of synaptic transmission in photoreceptor cells (measured by electroretinogram) induced by Scer\GAL4ninaE.PU-driven expression of Nc73EFGD4760.

      (Yoon et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Nc73EFGD4760
      Ogdh1GD4760
      OgdhGD4760
      Name Synonyms
      Secondary FlyBase IDs
        References (9)