FlyBase Allele Report: Dmel\Not1[GD9640]

General Information

Symbol

Dmel\Not1^GD9640

Species

D. melanogaster

Name

FlyBase ID

FBal0207779

Feature type

allele

Associated gene

Dmel\Not1

Associated Insertion(s)

Carried in Construct

P{GD9640}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9640}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9640

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Delta^UAS.cDa

(Vicente et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Not1^GD9640 under the control of Scer\GAL4^{elav.Switch.PO} (in combination with RU486 feeding) leads to increased memory index in courtship suppression assay in adults and in olfactory-mediated memory tests in larvae.

(Vissers et al., 2020)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in early pupal lethality or late larval lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9640

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | third instar larval stage | RU486 conditional phenotype, enhanceable by skd^VSH330726, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, enhanceable by ash1^GD14059, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | third instar larval stage | RU486 conditional phenotype, enhanceable by ash1^GD14059, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, enhanceable by mnb^GD13197, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | third instar larval stage | RU486 conditional phenotype, enhanceable by mnb^GD13197, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, enhanceable by Prosap^GD10101, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | third instar larval stage | RU486 conditional phenotype, enhanceable by Prosap^GD10101, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Not1^GD9640, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, enhanceable by skd^VSH330726, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Enhancer of

Statement

Reference

Not1^GD9640, Scer\GAL4^ey.PH is an enhancer of neoplasia | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Not1^GD9640, Scer\GAL4^ey.PH is an enhancer of visible | adult stage phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Not1^GD9640, Scer\GAL4^ey.PH is an enhancer of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v45463

w¹¹¹⁸; P{GD9640}v45463/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9640

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Not1^GD9640

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close