FlyBase Allele Report: Dmel\mnb[GD13197]

General Information

Symbol

Dmel\mnb^GD13197

Species

D. melanogaster

Name

FlyBase ID

FBal0210091

Feature type

allele

Associated gene

Dmel\mnb

Associated Insertion(s)

Carried in Construct

P{GD13197}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD13197}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD13197

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal feeding behavior | adult stage, with Scer\GAL4^sNPF-R.2.5

(Hong et al., 2012)

abnormal neuroanatomy | larval stage, with Scer\GAL4^Mhc.PK

(Lee et al., 2020)

decreased size | adult stage, with Scer\GAL4^bbg-C96

(Yang et al., 2016)

decreased size | adult stage, with Scer\GAL4^da.PU

(Yang et al., 2016)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible, with Scer\GAL4^rn.PU

(Degoutin et al., 2013)

visible | adult stage, with Scer\GAL4^bbg-C96

(Yang et al., 2016)

visible | adult stage, with Scer\GAL4^cv-c-C5

(Yang et al., 2016)

Phenotype Manifest In

adult brain, with Scer\GAL4^da.PU

(Yang et al., 2016)

eye, with Scer\GAL4^da.PU

(Yang et al., 2016)

neuromuscular junction, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

NMJ bouton | larval stage, with Scer\GAL4^Mhc.PK

(Lee et al., 2020)

synapse, with Scer\GAL4^elav-C155

(Bulat et al., 2014)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

wing, with Scer\GAL4^bbg-C96

(Yang et al., 2016)

wing, with Scer\GAL4^rn.PU

(Degoutin et al., 2013)

wing vein, with Scer\GAL4^cv-c-C5

(Yang et al., 2016)

wing vein L4, with Scer\GAL4^cv-c-C5

(Yang et al., 2016)

wing vein L5, with Scer\GAL4^cv-c-C5

(Yang et al., 2016)

Detailed Description

Statement

Reference

Expressing mnb^GD13197 under the control of Scer\GAL4^Mhc.PK leads to fewer boutons in the larval neuromuscular junction.

(Lee et al., 2020)

Presynaptic expression of mnb^GD13197 under the control of Scer\GAL4^elav-C155 causes synaptic retractions in less than 25% of neuromuscular junctions.

(Bulat et al., 2014)

Expression of mnb^GD13197 under the control of Scer\GAL4^rn.PU results in a significant reduction in wing size.

(Degoutin et al., 2013)

Flies expressing mnb^GD13197 under the control of Scer\GAL4^sNPF-R.2.5 show significantly decreased food consumption compared to controls.

Adults expressing mnb^GD13197 under the control of Scer\GAL4^sNPF-R.2.5 have a decreased body weight relative to controls.

Expression of mnb^GD13197 under the control of Scer\GAL4^Ilp2.PR has no significant effect on food intake in adults.

(Hong et al., 2012)

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 30-40% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 70-80% of the Scer\GAL4^pnr-MD237 expression domain.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

13197

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^cv-c-C5, mnb^GD13197 has visible | adult stage phenotype, enhanceable by cic³

(Yang et al., 2016)

Suppressed by

Statement

Reference

Scer\GAL4^bbg-C96, mnb^GD13197 has decreased size | adult stage phenotype, suppressible | partially by cic^KK113095/Scer\GAL4^bbg-C96

(Yang et al., 2016)

Scer\GAL4^bbg-C96, mnb^GD13197 has visible | adult stage phenotype, suppressible | partially by cic^KK113095/Scer\GAL4^bbg-C96

(Yang et al., 2016)

Scer\GAL4^da.PU, mnb^GD13197 has decreased size | adult stage phenotype, suppressible | partially by cic^KK113095/Scer\GAL4^da.PU

(Yang et al., 2016)

Enhancer of

Statement

Reference

mnb^GD13197, Scer\GAL4^{elav.Switch.PO} is an enhancer of abnormal memory | adult stage | RU486 conditional phenotype of Not1^GD9640, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

mnb^GD13197, Scer\GAL4^{elav.Switch.PO} is an enhancer of abnormal memory | third instar larval stage | RU486 conditional phenotype of Not1^GD9640, Scer\GAL4^{elav.Switch.PO}

(Vissers et al., 2020)

Suppressor of

Statement

Reference

Scer\GAL4^sNPF-R.2.5/mnb^GD13197 is a suppressor of abnormal feeding behavior | adult stage phenotype of Scer\GAL4^sNPF-R.2.5, sNPF-R^UAS.cLa

(Hong et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^cv-c-C5, mnb^GD13197 has wing vein L5 phenotype, enhanceable by cic³

(Yang et al., 2016)

Scer\GAL4^cv-c-C5, mnb^GD13197 has wing vein L4 phenotype, enhanceable by cic³

(Yang et al., 2016)

Scer\GAL4^cv-c-C5, mnb^GD13197 has wing vein phenotype, enhanceable by cic³

(Yang et al., 2016)

Suppressed by

Statement

Reference

Scer\GAL4^bbg-C96, mnb^GD13197 has wing phenotype, suppressible | partially by cic^KK113095/Scer\GAL4^bbg-C96

(Yang et al., 2016)

Scer\GAL4^da.PU, mnb^GD13197 has adult brain phenotype, suppressible | partially by cic^KK113095/Scer\GAL4^da.PU

(Yang et al., 2016)

Scer\GAL4^da.PU, mnb^GD13197 has eye phenotype, suppressible | partially by cic^KK113095/Scer\GAL4^da.PU

(Yang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in food consumption compared to controls seen in adults expressing sNPF-R^Scer\UAS.cLa under the control of Scer\GAL4^sNPF-R.2.5 is suppressed by co-expression of mnb^GD13197.

(Hong et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v28628

w¹¹¹⁸; P{GD13197}v28628/TM3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

13197

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DYRK1a^RNAi

(Vissers et al., 2020)

Mnb¹

(Bulat et al., 2014)

mnb^GD13197

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

Open Close