FlyBase Allele Report: Dmel\cic[3]

General Information

Symbol

Dmel\cic³

Species

D. melanogaster

Name

FlyBase ID

FBal0359767

Feature type

allele

Associated gene

Dmel\cic

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

gain of function allele

(Papagianni et al., 2018, Forés et al., 2017)

Mutagen

CRISPR/Cas9

(Papagianni et al., 2018, Forés et al., 2017, Yang et al., 2016)

Progenitor genotype

Cytology

Description

Deletion of a single conserved F residue (QFI) in the C2 motif.

(Papagianni et al., 2018)

Deletion of a single conserved F residue in the C2 motif.

(Forés et al., 2017)

Mutation within cic, resulting in deletion of amino acid residue F1054 from the encoded protein. This lesion is predicted to specifically disrupt the interaction of cic protein with rl protein.

(Yang et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:20,298,947..20,298,949 [+]

Comment:

Deletion of a single conserved F residue (QFI) in the C2 motif.

Comment:

Deletion of amino acid residue F1054

Comment:

Deletion of a single conserved F residue in the C2 motif.

(Papagianni et al., 2018, Forés et al., 2017, Yang et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage

(Yang et al., 2016)

Phenotype Manifest In

wing vein L5

(Yang et al., 2016)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cic³ is an enhancer of visible | adult stage phenotype of Scer\GAL4^cv-c-C5, mnb^GD13197

(Yang et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

cic³ is an enhancer of wing vein L5 phenotype of Scer\GAL4^cv-c-C5, mnb^GD13197

(Yang et al., 2016)

cic³ is an enhancer of wing vein L4 phenotype of Scer\GAL4^cv-c-C5, mnb^GD13197

(Yang et al., 2016)

cic³ is an enhancer of wing vein phenotype of Scer\GAL4^cv-c-C5, mnb^GD13197

(Yang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cic³

(Papagianni et al., 2018, Forés et al., 2017, Yang et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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