FlyBase Allele Report: Dmel\sxc[GD6968]

General Information

Symbol

Dmel\sxc^GD6968

Species

D. melanogaster

Name

FlyBase ID

FBal0207873

Feature type

allele

Associated gene

Dmel\sxc

Associated Insertion(s)

Carried in Construct

P{GD6968}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD6968}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD6968

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of non-syndromic X-linked intellectual disability 106

CEA

(Fenckova et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

abnormal locomotor rhythm, with Scer\GAL4^tim.UAS

(Kaasik et al., 2013)

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

(Sekine et al., 2010)

decreased body size | third instar larval stage, with Scer\GAL4^Ilp2.PR

(Sekine et al., 2010)

decreased cell number | adult stage, with Scer\GAL4^NP7397

(Na et al., 2022)

decreased occurrence of cell division | adult stage, with Scer\GAL4^NP7397

(Na et al., 2022)

increased cell number | adult stage, with Scer\GAL4^NP0001

(Na et al., 2022)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

(Na et al., 2022)

lethal, with Scer\GAL4^Tub.PU

(Sekine et al., 2010)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

partially lethal - majority die | female, with Scer\GAL4^esg.PU

(Akan et al., 2021)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible | adult stage, with Scer\GAL4^esg.PU

(Akan et al., 2021)

Phenotype Manifest In

adult midgut epithelium, with Scer\GAL4^NP0001

(Na et al., 2022)

adult midgut epithelium, with Scer\GAL4^NP7397

(Na et al., 2022)

adult midgut progenitor cell, with Scer\GAL4^NP7397

(Na et al., 2022)

intestinal stem cell | adult stage | increased number, with Scer\GAL4^NP0001

(Na et al., 2022)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

wing, with Scer\GAL4^esg.PU

(Akan et al., 2021)

Detailed Description

Statement

Reference

Expression of sxc^GD6968 under the control of Scer\GAL4^tim.Scer\UAS results in shortening of the period of the free-running locomotor activity rhythm in constant darkness.

(Kaasik et al., 2013)

Adults expressing sxc^GD6968 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in defects in locomotion or a weak flyer phenotype.

(Schnorrer et al., 2010)

Third instar larvae and adults expressing sxc^GD6968 under the control of Scer\GAL4^Ilp2.PR have a significantly reduced body size compared to controls.

Expression of sxc^GD6968 under the control of Scer\GAL4^Ilp2.PR is not overtly toxic to insulin-producing cells (IPCs); the IPC nuclei in third larval instar brains do not show any changes that would be consistent with apoptosis or necrosis.

Hemolymph carbohydrate levels are increased in third instar larvae and adults expressing sxc^GD6968 under the control of Scer\GAL4^Ilp2.PR compared to controls.

Expression of sxc^GD6968 under the control of Scer\GAL4^Lsp2.PH reduces the accumulation of neutral lipids in the fat body compared to controls.

(Sekine et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 0% or 80-90% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 may result in mild thorax closure defects, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 may result in an enlarged notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6968

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v18610

w¹¹¹⁸; P{GD6968}v18610

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

6968

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

OGT^RNAi

(Na et al., 2015)

Ogt^GD6968

sxc^GD6968

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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