FlyBase Allele Report: Dmel\Tom70[GD5520]

General Information

Symbol

Dmel\Tom70^GD5520

Species

D. melanogaster

Name

FlyBase ID

FBal0208815

Feature type

allele

Associated gene

Dmel\Tom70

Associated Insertion(s)

Carried in Construct

P{GD5520}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD5520}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD5520

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of mitochondrial metabolism disease

CEA

(Dutta et al., 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Detailed Description

Statement

Reference

Expressing Tom70^GD5520 under the control of Scer\GAL4^GMR.PU induces a glossy eye phenotype. In electroretinograms, the amplitudes of the depolarization is not changed but there is loss in amplitude of the ON and OFF transients.

(Dutta et al., 2020)

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5520

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Tom70^GD5520 has visible | adult stage | progressive phenotype, suppressible | partially by Hsap\TOMM70^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Scer\GAL4^GMR.PU, Tom70^GD5520 has abnormal neurophysiology | adult stage phenotype, suppressible by Hsap\TOMM70^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Tom70^GD5520 has visible | adult stage | progressive phenotype, non-suppressible by Hsap\TOMM70^{I554F.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Scer\GAL4^GMR.PU, Tom70^GD5520 has abnormal neurophysiology | adult stage phenotype, non-suppressible by Hsap\TOMM70^{I554F.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Scer\GAL4^GMR.PU, Tom70^GD5520 has abnormal neurophysiology | adult stage phenotype, non-suppressible by Hsap\TOMM70^{T607I.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Scer\GAL4^GMR.PU, Tom70^GD5520 has visible | adult stage | progressive phenotype, non-suppressible by Hsap\TOMM70^{T607I.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Tom70^GD5520 has eye phenotype, suppressible | partially by Hsap\TOMM70^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Tom70^GD5520 has eye phenotype, non-suppressible by Hsap\TOMM70^{I554F.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

Scer\GAL4^GMR.PU, Tom70^GD5520 has eye phenotype, non-suppressible by Hsap\TOMM70^{T607I.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Dutta et al., 2020)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Mef2.PR/Tom70^GD5520 is a non-suppressor of endoplasmic reticulum | larval stage phenotype of Pink1^B9

(Ham et al., 2023)

Scer\GAL4^Mef2.PR/Tom70^GD5520 is a non-suppressor of larval muscle cell | larval stage phenotype of Pink1^B9

(Ham et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v18112

w¹¹¹⁸; P{GD5520}v18112

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5520

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Tom70^GD5520

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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