Expressing eIF4AGD14111 under the control of Scer\GAL4repo results in decreased glial cell numbers in the eye discs and optic stalks of third instar larvae. Photoreceptor axon targeting to the optic stalk is unaffected. GAL80ts was used to induce eIF4AGD14111 expression from 72 hours after larval hatching onwards.
Adults expressing eIF-4aGD14111 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in early larval lethality or late larval lethality.
Expression under the control of Scer\GAL4Mef2.PR results in grossly normal larval body wall muscles.
Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.
Expression under the control of Scer\GAL4pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.