FlyBase Allele Report: Dmel\grim[GD11287]

General Information

Symbol

Dmel\grim^GD11287

Species

D. melanogaster

Name

FlyBase ID

FBal0209655

Feature type

allele

Associated gene

Dmel\grim

Associated Insertion(s)

Carried in Construct

P{GD11287}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD11287}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD11287

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^Act5C.PI

(Tan et al., 2011)

decreased cell death | larval stage, with Scer\GAL4^Act5C.PI

(Tan et al., 2011)

lethal, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

lethal | pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

abdominal neuroblast, with Scer\GAL4^Act5C.PI

(Tan et al., 2011)

Detailed Description

Statement

Reference

Expression of grim^GD11287 under the control of Scer\GAL4^Act5C.PI leads to an increase in larval abdominal neuroblasts compared with wild-type.

(Tan et al., 2011)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality (either before or at the pupal stage), depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11287

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Scer\GAL4^hh.PU/grim^GD11287 is a non-suppressor of increased cell death | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

grim^GD11287 is a non-suppressor of increased cell death phenotype of Scer\GAL4^ap-nd432, nab^EP-nd642

(Suissa et al., 2011)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Scer\GAL4^hh.PU/grim^GD11287 is a non-suppressor of wing disc posterior compartment | larval stage phenotype of Scer\GAL4^hh.PU, Spyo\Cas9^UAS.P2, wg^{UAS.wg+intergenic-1.pCFD6}

(Ewen-Campen and Perrimon, 2024)

grim^GD11287 is a non-suppressor of wing disc phenotype of Scer\GAL4^ap-nd432, nab^EP-nd642

(Suissa et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

No change in nab^EP642-induced apoptosis in the dorsal compartment of the wing imaginal disc (using the Scer\GAL4^ap.nd432 driver) is found upon co-expression of grim^GD11287.

(Suissa et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v21830

w¹¹¹⁸; P{GD11287}v21830

v22597

w¹¹¹⁸; P{GD11287}v22597

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

11287

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

grim^GD11287

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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