FlyBase Allele Report: Dmel\pcm[GD10926]

FB2026_02 , released June 18, 2026

FB2026_02 , released June 18, 2026

Allele: Dmel\pcm^GD10926

General Information

Symbol

Dmel\pcm^GD10926

Species

D. melanogaster

Name

FlyBase ID

FBal0210305

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

abnormal size | third instar larval stage, with Scer\GAL4^69B

(Waldron et al., 2015)

abnormal size | third instar larval stage, with Scer\GAL4^nub-AC-62

(Waldron et al., 2015)

increased cell death, with Scer\GAL4^69B

(Waldron et al., 2015)

increased cell death, with Scer\GAL4^en.PU

(Waldron et al., 2015)

increased cell death, with Scer\GAL4^nub-AC-62

(Waldron et al., 2015)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^69B

(Waldron et al., 2015)

visible, with Scer\GAL4^en.PU

(Waldron et al., 2015)

visible, with Scer\GAL4^nub-AC-62

(Waldron et al., 2015)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

posterior wing margin, with Scer\GAL4^en.PU

(Waldron et al., 2015)

wing blade, with Scer\GAL4^69B

(Waldron et al., 2015)

wing blade, with Scer\GAL4^en.PU

(Waldron et al., 2015)

wing blade, with Scer\GAL4^nub-AC-62

(Waldron et al., 2015)

wing pouch, with Scer\GAL4^69B

(Waldron et al., 2015)

wing pouch, with Scer\GAL4^en.PU

(Waldron et al., 2015)

wing pouch, with Scer\GAL4^nub-AC-62

(Waldron et al., 2015)

wing vein, with Scer\GAL4^69B

(Waldron et al., 2015)

wing vein, with Scer\GAL4^en.PU

(Waldron et al., 2015)

wing vein, with Scer\GAL4^nub-AC-62

(Waldron et al., 2015)

Detailed Description

Statement

Reference

Expression of pcm^GD10926 under the control of either Scer\GAL4^69B or Scer\GAL4^nub-AC-62 results in smaller adult wing size and vein defects (including loss of anterior cross vein, shortened L5 and/or posterior cross vein). Expression under the control of Scer\GAL4^en.PU leads to loss of tissue, notches, blisters as well as vein defects only in the posterior compartment of the adult wing.

The pcm^GD10926 expression under the control of Scer\GAL4^nub-AC-62 results in increased apoptosis (assessed by Caspase-3 antibody staining) in the wing pouch of third instar larval wing disc and the increased apoptosis is still limited to the wing pouch when the RNAi is driven by Scer\GAL4^69B or to the posterior part of the wing pouch when driven by Scer\GAL4^en.PU.

(Waldron et al., 2015)

Adults expressing pcm^GD10926 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in a weak flyer phenotype.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 80-90% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

10926

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

v21677

w¹¹¹⁸; P{GD10926}v21677

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

10926

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pcm^GD10926

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections