FlyBase Allele Report: Dmel\tor[GD14396]

General Information

Symbol

Dmel\tor^GD14396

Species

D. melanogaster

Name

FlyBase ID

FBal0210783

Feature type

allele

Associated gene

Dmel\tor

Associated Insertion(s)

Carried in Construct

P{GD14396}

Also Known As

torso-RNAi, UAS-torso-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14396}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14396

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm, with Scer\GAL4^phtm.PU

(Cavieres-Lepe et al., 2024)

abnormal developmental rate, with Scer\GAL4^phtm.PO

(Rewitz et al., 2009)

abnormal eclosion rhythm, with Scer\GAL4^phtm.PO

(Selcho et al., 2017)

abnormal eclosion rhythm, with Scer\GAL4^tim.PE

(Selcho et al., 2017)

abnormal phototaxis | third instar larval stage, with Scer\GAL4^elav-C155

(Yamanaka et al., 2013)

abnormal phototaxis | third instar larval stage, with Scer\GAL4^GMR.PFa

(Yamanaka et al., 2013)

abnormal phototaxis | third instar larval stage, with Scer\GAL4^GMR.PFa, Scer\GAL4^ppk.1.9

(Yamanaka et al., 2013)

abnormal phototaxis | third instar larval stage, with Scer\GAL4^Kr.5.1

(Yamanaka et al., 2013)

abnormal phototaxis | third instar larval stage, with Scer\GAL4^ppk.1.9

(Yamanaka et al., 2013)

abnormal phototaxis | third instar larval stage, with Scer\GAL4^αTub84B.PL

(Yamanaka et al., 2013)

abnormal size | larval stage | somatic clone, with Scer\GAL4^NP0394

(Shimell et al., 2018)

increased body size, with Scer\GAL4^phtm.PO

(Rewitz et al., 2009)

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

nucleus | larval stage | somatic clone, with Scer\GAL4^NP0394

(Shimell et al., 2018)

prothoracic gland | larval stage | somatic clone, with Scer\GAL4^NP0394

(Shimell et al., 2018)

pupa, with Scer\GAL4^phtm.PO

(Rewitz et al., 2009)

Detailed Description

Statement

Reference

Prothoracic gland clones expressing tor^GD14396 under the control of Scer\GAL4^Act5C.PI have smaller nuclei than neighboring cells.

(Shimell et al., 2018)

Expression of tor^GD14396 under the control of Scer\GAL4^phm.PO or Scer\GAL4^tim.PE significantly reduces the circadian rhythmicity of adult emergence after transfer to constant darkness, compared to controls; this effect does not occur when tor^GD14396 is expressed under the control of both Scer\GAL4^tim.PE and Scer\GAL80^phm.1.2. Expression of tor^GD14396 under the control of Scer\GAL4^phm.PO, or the combination of Scer\GAL4^tim.PE and Scer\GAL80^phm.1.2, does not affect the rhythmicity of adult locomotor behavior, compared to controls.

(Selcho et al., 2017)

Expression of Scer\GAL4^elav-C155>tor^GD14396 results in the loss of light avoidance in larvae.

Expression of Scer\GAL4^αTub84B.PL>tor^GD14396 results in the loss of light avoidance in larvae.

Expression of Scer\GAL4^Ptth.cMa>tor^GD14396 does not cause any change in larval light avoidance.

Expression of Scer\GAL4^Kr.5.1>tor^GD14396 in the Bolwig's organ abolishes larval light avoidance.

Expression of Scer\GAL4^GMR.PFa>tor^GD14396 in the Bolwig's organ abolishes larval light avoidance.

Expression of Scer\GAL4^ppk.1.9>tor^GD14396 in class IV da neurons abolishes larval light avoidance.

Expression of Scer\GAL4^GMR.PFa>tor^GD14396 in motorneurons fails to abolish larval light avoidance.

(Yamanaka et al., 2013)

Scer\GAL4^phm.PO-driven expression of tor^GD14396 in larvae delays pupariation by 5.8 days as compared with Scer\GAL4^phm.PO-control animals, and it leads to excessive growth during the prolonged third instar larval stage, resulting in increased pupal size. Feeding Scer\GAL4^phm.PO>tor^GD14396 larvae with 20-hydroxyecdysone completely rescues the developmental delay and overgrowth.

(Rewitz et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14396

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^phtm.PO, tor^GD14396 has increased body size phenotype, suppressible by Ras85D^V12.UAS, Scer\GAL4^phtm.PO

(Rewitz et al., 2009)

Scer\GAL4^phtm.PO, tor^GD14396 has abnormal developmental rate phenotype, suppressible by Ras85D^V12.UAS, Scer\GAL4^phtm.PO

(Rewitz et al., 2009)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of the constitutively active Ras85D^V12.Scer\UAS suppresses the Scer\GAL4^phm.PO-driven tor^GD14396-induced delay and overgrowth phenotype.

(Rewitz et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v36280

w¹¹¹⁸; P{GD14396}v36280

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14396

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

tor^GD14396

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

Open Close