FlyBase Allele Report: Dmel\wls[GD2418]

General Information

Symbol

Dmel\wls^GD2418

Species

D. melanogaster

Name

FlyBase ID

FBal0210893

Feature type

allele

Associated gene

Dmel\wls

Associated Insertion(s)

Carried in Construct

P{GD2418}

Also Known As

wls RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2418}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2418

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

abnormal wound healing, with Scer\GAL4^A58

(Thyagarajan et al., 2025)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

larval dorsal multidendritic neuron ddaE | conditional, with Scer\GAL4^A58

(Thyagarajan et al., 2025)

microtubule | conditional, with Scer\GAL4^A58

(Thyagarajan et al., 2025)

wing blade, with Scer\GAL4^dpp.PU

(Kim et al., 2016)

Detailed Description

Statement

Reference

Expression of wls^GD2418 under the control of Scer\GAL4^dpp.PU results in notched wing phenotype in adult flies.

(Kim et al., 2016)

Expression of wls^GD2418 under the control of Scer\GAL4^dsx.KI does not significantly reduce exosome secretion into the accessory gland lumen compared to controls.

(Corrigan et al., 2014)

Adults expressing wls^GD2418 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) can show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies, depending on the particular P{GD2418} insertion line used.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2418

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^dpp.PU, wls^GD2418 has visible | adult stage phenotype, suppressible by sona^UAS.cKa/Scer\GAL4^dpp.PU

(Kim et al., 2016)

NOT suppressed by

Statement

Reference

Scer\GAL4^dpp.PU, wls^GD2418 has visible | adult stage phenotype, non-suppressible by Scer\GAL4^dpp.PU/sona^E475A.UAS

(Kim et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^dpp.PU, wls^GD2418 has wing blade phenotype, suppressible by sona^UAS.cKa/Scer\GAL4^dpp.PU

(Kim et al., 2016)

NOT suppressed by

Statement

Reference

Scer\GAL4^dpp.PU, wls^GD2418 has wing blade phenotype, non-suppressible by Scer\GAL4^dpp.PU/sona^E475A.UAS

(Kim et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The notched wing phenotype observed in flies expressing wls^GD2418 under the control of Scer\GAL4^dpp.PU is fully rescued by co-expression of sona^Scer\UAS.cKa but not by co-expression of sona^{E475A.Scer\UAS}.

(Kim et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v5214