FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\β-SpecΔPH.Ubi-p63E.Tag:MYC
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General Information
Symbol
Dmel\β-SpecΔPH.Ubi-p63E.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0212748
Feature type
allele
Associated gene
Dmel\β-Spec
Associated Insertion(s)
Carried in Construct
P{Ubi-p63E-β-Spec.ΔPH}
Key Links
Transgenic product class
inframe_deletion
(Das et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Das et al., 2006)
Mutagen
in vitro construct
(Das et al., 2006)
Progenitor genotype
Carried in construct
P{Ubi-p63E-β-Spec.ΔPH}
Cytology
Description

An Ubi-p63E promoter drives expression of a truncated form of β-Spec that lacks the PH domain. The construct is tagged with Tag:MYC.

(Das et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
β-Spec
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease 1
      modeled by Hsap\SNCAQUAS.cOa
      (Maor et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of β-SpecΔPH.Ubi-p63E.T:Hsap\MYC in a β-Specem21 background rescues flies rarely. These rescued flies are strikingly small in size and are sterile.

      (Das et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      β-SpecΔPH.Ubi-p63E.Tag:MYC partially rescues β-Specem6

      (Garbe et al., 2007)
      Fails to rescue

      β-SpecΔPH.Ubi-p63E.Tag:MYC fails to rescue β-Specem21

      (Das et al., 2006)
      Comments

      Expression of β-SpecΔPH.Ubi-p63E.T:Hsap\MYC rescues the midline axon guidance defects of β-Specem6/Y embryos.

      (Garbe et al., 2007)

      Expression of β-SpecΔPH.Ubi-p63E.T:Hsap\MYC generally fails to rescue β-Specem21 flies, although rare rescue flies are observed.

      (Das et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      β-SpecΔPH.Ubi-p63E.T:Hsap\MYC
      β-SpecΔPH.Ubi-p63E.Tag:MYC
      βspecΔPH
      (Das et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)