FB2026_02 , released June 18, 2026
Allele: Dmel\Pp1α-96A2
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General Information
Symbol
Dmel\Pp1α-96A2
Species
D. melanogaster
Name
FlyBase ID
FBal0212815
Feature type
allele
Associated gene
Dmel\Pp1α-96A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kirchner et al., 2007)
Mutagen
Delta2-3 transposase
(Kirchner et al., 2007)
Progenitor genotype
Pp1α-96AGS11179
(Kirchner et al., 2007)
Cytology
Description

Imprecise excision of the insertion in Pp1α-96AGS11179, resulting in a 1.7kb deletion, which removes the proximal promoter region, transcription start site and exons 1-3 of Pp1α-96A.

(Kirchner et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pp1-87B87Bg-3 Pp1α-96A2 double heterozygous embryos exhibit damped (and spatially more confined) oscillations in the Cdk1/PP1 activity ratio, reduced cortical contractions and cytoplasmic flows, non-uniform positioning, tissue-wide asynchronies, and anaphase delays when compared to controls.

      (Deneke et al., 2019)

      Homozygotes have no obvious mutant phenotype.

      (Kirchner et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Pp1α-96A2, Pp1-87B87Bg-3/Pp1-87B1 has lethal phenotype, non-suppressible by flwUAS.Tag:HA/Scer\GAL4arm.PS

      (Kirchner et al., 2007)
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Pp1α-96A2, Pp1-87B87Bg-3 has embryo phenotype, suppressible | partially by grp209/grpZ5170, lok30/lok30

      (Deneke et al., 2019)
      Other
      Statement
      Reference

      Pp1α-96A2, Pp1-87B87Bg-3 has embryo phenotype

      (Deneke et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pp1-87B1/Pp1-87B87Bg-3 Pp1α-96A2/Pp1α-96A2 double mutant animals die slightly earlier than Pp1-87B1/Pp1-87B87Bg-3 single mutants and pupariate 1-2 days later than their siblings.

      (Kirchner et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      PP1α96A2
      (Kirchner et al., 2007)
      Pp1alpha-96A2
      (Deneke et al., 2019)
      Pp1α-96A2
      (Agrawal and Hardin, 2016, Swanhart et al., 2007)
      pp1α-96A2
      (Moreira et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)