Open Close
General Information
Symbol
Dmel\hiwΔRING.UAS.Tag:TAP
Species
D. melanogaster
Name
FlyBase ID
FBal0215868
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-NTAP-hiwΔRING
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: C4991S.

UAS regulatory sequences drive expression of hiw coding sequence in which the first two cysteine residues (C4991 and C4994) in the RING domain are mutagenised to serine, with a Tag:TAP tag at the N-terminus.

Amino acid replacement: C4994S.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of hiwΔRING.Scer\UAS.T:Zzzz\TAP through the strong neuronal driver Scer\GAL4elav.Switch.PO results in a more than twofold increase in both the number of boutons and the number of branchpoints, a 50% increase in synaptic span and a 50% reduction in bouton size.

Expression of hiwΔRING.Scer\UAS.T:Zzzz\TAP under the control of Scer\GAL4elav.Switch.PO in a hiwND8 heterozygous background leads to an additional 56% increase in the number of boutons and an additional 42% increase in the number of branch points, compared with the expression of hiwΔRING.Scer\UAS in a wild-type background.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of hiwΔRING.Scer\UAS.T:Zzzz\TAP under the control of Scer\GAL4elav.PLu is unable to rescue either the quantal size or quantal content defects of hiwND8 hemizygotes.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
hiwΔRING.Scer\UAS.T:Zzzz\TAP
hiwΔRING.UAS.Tag:TAP
Name Synonyms
Secondary FlyBase IDs
    References (3)