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General Information
Symbol
Dmel\Doa69.long3'UTR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0216677
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a complete cDNA of the 69kDa Doa isoform from the RE21871 cDNA, including the full length 3' UTR.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Doa69.long3'UTR.Scer\UAS under the control of Scer\GAL4Lsp2.PH results in male lethality and reduced viability of females.

Expression of Doa69.long3'UTR.Scer\UAS under the control of Scer\GAL4GMR.PF results in ommatidial fusion and disorganisation. Small holes are seen in the surface of the ommatidia at high magnification.

Expression of Doa69.long3'UTR.Scer\UAS under the control of Scer\GAL4da.G32 results in lethality with no escapers.

Expression of Doa69.long3'UTR.Scer\UAS under the control of Scer\GAL4GMR.PF results in a variable eye phenotype (ranging from roughened eyes, fused and missing ommatidia and pigment loss, through to almost complete elimination of the facets, with little if any pigment and a greatly reduced eye size), depending on the particular P{UAS-Doa.69.long3'UTR} insertion line used and the temperature.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Doa69.long3'UTR.Scer\UAS under the control of Scer\GAL4bam.T:Hsim\VP16 almost completely rescues the sterility of DoaDem/DoaHD males.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Doa69.long3'UTR.Scer\UAS
Doa69.long3'UTR.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)