FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dawaact1
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General Information
Symbol
Dmel\dawaact1
Species
D. melanogaster
Name
FlyBase ID
FBal0217504
Feature type
allele
Associated gene
Dmel\daw
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Gesualdi and Haerry, 2007)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    dawaact1 contains a 2.5kb deletion, including the second promoter, the start codon, and most of the coding sequence.

    (Gesualdi and Haerry, 2007)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        A small number of dawaact1 mutants survive till adulthood (i.e ~5%). Those that do survive exhibit normal-sized wings compared to those of heterozygous animals. They are fertile, but most of the progeny die and exhibit daw mutant phenotype.

        dawaact1 mutants are not embryonic lethal and do not show obvious abnormalities in mesodermal tissues. Most dawaact1 mutant animals die during larval development. Mutant larvae exhibit the bloated anal pad phenotype of babo mutants.

        (Gesualdi and Haerry, 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of ActβCM.Scer\UAS in a dawaact1 background under the control of the neurosecretory driver Scer\GAL4386Y fails to suppress dawaact1 lethality.

        Expression of baboQ302D.Scer\UAS in a dawaact1 background under the control of the neurosecretory driver Scer\GAL4386Y fails to suppress dawaact1 lethality.

        (Gesualdi and Haerry, 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        dawaact1 is rescued by Scer\GAL4da.G32/dawUAS.cGa

        (Gesualdi and Haerry, 2007)

        dawaact1 is rescued by Scer\GAL4hs.PB-Ubi/dawUAS.cGa

        (Gesualdi and Haerry, 2007)

        dawaact1 is rescued by Scer\GAL4386Y/dawUAS.cGa

        (Gesualdi and Haerry, 2007)

        dawaact1 is rescued by Scer\GAL4phtm.PO/dawUAS.cGa

        (Gesualdi and Haerry, 2007)
        Comments

        dawaact1 mutant animals can be rescued by ubiquitous expression of dawScer\UAS.cGa using Scer\GAL4da.G32 and Scer\GAL4hs.PB-Ubi (to 66% and 56% of wild-type, respectively).

        Expression of dawScer\UAS.cGa using the neurosecretory driver Scer\GAL4386Y rescues the anal pad phenotype of dawaact1 mutants, with approximately 89% of the expected homozygous animals surviving to become fertile adults.

        Expression of dawScer\UAS.cGa using the Scer\GAL4phm.PO driver, to localise expression to the prothoracic portion of the ring gland, results in rescue of lethality of 84% of dawaact1 mutants.

        (Gesualdi and Haerry, 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        DawAcct1
        (Chng et al., 2014)
        dawaact1
        (Gesualdi and Haerry, 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)