FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tgs1um.t4.6
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General Information
Symbol
Dmel\Tgs1um.t4.6
Species
D. melanogaster
Name
FlyBase ID
FBal0218463
Feature type
allele
Associated gene
Dmel\Tgs1
Associated Insertion(s)
Carried in Construct
P{CaSpeR-DTLum}
Also Known As
pCaSpeR-DTLum
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Komonyi et al., 2005)
Progenitor genotype
Tgs1+t4.6
(Komonyi et al., 2005)
Carried in construct
P{CaSpeR-DTLum}
Cytology
Description

A synthetic oligo (CTAGTCTAGACTAG) has introduced stop codons in all 3 reading frames at +502 bp relative to the common transcription initiation site of Tgs1 and moi. This introduces a stop codon into moi, but does not affect the sequence of Tgs1.

(Komonyi et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
Tgs1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Tgs1um.t4.6 rescues Df(3R)d189/Tgs1S096713

      (Komonyi et al., 2009)
      Partially rescues

      Tgs1um.t4.6 partially rescues Df(3R)d189/Df(3R)d192

      (Komonyi et al., 2009)
      Fails to rescue

      Tgs1um.t4.6 fails to rescue Df(3R)d189/Df(3R)d192

      (Komonyi et al., 2009)
      Comments

      The presence of P{CaSpeR-DTLum} (expressing wild type Tgs1) delays the lethality phase of Df(3R)d192/Df(3R)d189 and P{lacW}moiS096713/Df(3R)d189 animals, with these animals now dying at the early pupa stage or hatching, respectively. However, aberrant telomere associations in Df(3R)d192/Df(3R)d189 larval neuroblasts are not rescued.

      (Komonyi et al., 2009)

      The P3-P4 early pupal lethality seen in P{lacW}moiS096713/Df(3R)d189 animals is partially rescued by P{CaSpeR-DTLum} (which carries tatlum.t4.6 and moium.t4.6); animals die as pharate adults or immediately after hatching.

      The P3-P4 early pupal lethality seen in P{lacW}moiS096713/Df(3R)d189 animals is completely rescued by P{CaSpeR-DTLdm} and P{CaSpeR-DTLum} together in trans.

      (Komonyi et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tgs1um.t4.6
      tatlum.t4.6
      Name Synonyms
      Secondary FlyBase IDs
        References (2)