FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tgs1S096713
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General Information
Symbol
Dmel\Tgs1S096713
Species
D. melanogaster
Name
FlyBase ID
FBal0218459
Feature type
allele
Associated gene
Dmel\Tgs1
Associated Insertion(s)
P{lacW}moiS096713
Carried in Construct
Also Known As
l(3)S096713
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Komonyi et al., 2009)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lacW}moiS096713
    Cytology
    Description

    P{lacW} insertion upstream of the upstream open reading frame (moi) of the dicistronic locus that encodes both moi and tatl.

    (Raffa et al., 2009)

    Insertion 35bp downstream of the tatl and moi common transcriptional start.

    (Komonyi et al., 2005)
    Allele components
    Component
    Use(s)
    Inserted element
    P{lacW}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies homozygous for the P{lacW}moiS096713 insertion die as third instar larvae.

        (Deak et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Df(3R)d189/Tgs1S096713 is rescued by Tgs1+t4.6

        (Komonyi et al., 2009)

        Df(3R)d189/Tgs1S096713 is rescued by Tgs1um.t4.6

        (Komonyi et al., 2009)
        Comments

        P{CaSpeR-DTL} (expressing wild type moi and Tgs1) rescues the lethality of P{lacW}moiS096713/Df(3R)d189.

        The presence of P{CaSpeR-DTLum} (expressing wild type Tgs1) delays the lethality phase of P{lacW}moiS096713/Df(3R)d189 animals, with these animals now hatching.

        (Komonyi et al., 2009)

        The P3-P4 early pupal lethality seen in P{lacW}moiS096713/Df(3R)d189 animals is completely rescued by P{CaSpeR-DTL} (which carries moi+t4.6 and tatl+t4.6).

        The P3-P4 early pupal lethality seen in P{lacW}moiS096713/Df(3R)d189 animals is not rescued by P{CaSpeR-DTLdm} (which carries tatldm.t4.6 and moidm.t4.6).

        The P3-P4 early pupal lethality seen in P{lacW}moiS096713/Df(3R)d189 animals is partially rescued by P{CaSpeR-DTLum} (which carries tatlum.t4.6 and moium.t4.6); animals die as pharate adults or immediately after hatching.

        The P3-P4 early pupal lethality seen in P{lacW}moiS096713/Df(3R)d189 animals is completely rescued by P{CaSpeR-DTLdm} and P{CaSpeR-DTLum} together in trans.

        (Komonyi et al., 2005)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        The P{lacW}moiS096713 insertion maps upstream of a dicistronic locus that encodes moi (upstream ORF) and tatl (downstream ORF). Rescue analysis indicates that the telomere fusion phenotype seen in P{lacW}moiS096713 mutants is due to an effect on the moi ORF and not on tatl. In contrast, the lethality caused by the insertion is not rescued by a transgene containing either ORF alone, but is rescued by a transgene containing functional copies of both ORFs, indicating that the lethality is due to an effect on both ORFs.

        (Raffa et al., 2009)

        Associated with: moiS096713.

        (Raffa et al., 2009)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Tgs1S096713
        l(3)S096713
        (Raffa et al., 2009, Pankotai et al., 2005)
        tatlS096713
        Name Synonyms
        Secondary FlyBase IDs
          References (6)