FB2026_02 , released June 18, 2026
Allele: Dmel\upSETMB08950
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General Information
Symbol
Dmel\upSETMB08950
Species
D. melanogaster
Name
FlyBase ID
FBal0218835
Feature type
allele
Associated gene
Dmel\upSET
Associated Insertion(s)
Mi{ET1}upSETMB08950
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}upSETMB08950
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        upSETMB08950/CG9007[+] is an enhancer of homeotic | dominant | male phenotype of Pc1

        (Rincon-Arano et al., 2012)

        upSETMB08950/CG9007[+] is an enhancer of homeotic | dominant | male phenotype of Pc3

        (Rincon-Arano et al., 2012)
        Suppressor of
        Statement
        Reference

        upSETMB08950/CG9007[+] is a suppressor of homeotic | dominant phenotype of brm[+]/brm2, trxE2

        (Rincon-Arano et al., 2012)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        upSETMB08950/CG9007[+] is an enhancer of sex comb | ectopic | male phenotype of Pc1

        (Rincon-Arano et al., 2012)

        upSETMB08950/CG9007[+] is an enhancer of sex comb | ectopic | male phenotype of Pc3

        (Rincon-Arano et al., 2012)
        Suppressor of
        Statement
        Reference

        upSETMB08950/CG9007[+] is a suppressor of metathoracic leg phenotype of brm[+]/brm2, trxE2

        (Rincon-Arano et al., 2012)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The penetrance of the ectopic sex comb phenotype seen on the second and/or third legs of Pc3/+ flies (40%) is enhanced if they are also heterozygous for upSETMB08950 (76%).

        The penetrance of the ectopic sex comb phenotype seen on the second and/or third legs of Pc1/+ flies (33%) is enhanced if they are also heterozygous for upSETMB08950 (75%).

        56% of brm2 trxE2 double heterozygotes have an apical bristle on the third leg (usually found on the second leg). Heterozygosity for upSETMB08950 reduces the penetrance of this phenotype to 4%.

        (Rincon-Arano et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG9007MB08950
        (Bellen, 2008.11.7)
        upSETMB08950
        (Rincon-Arano et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)