FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Rbsn-540-3
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General Information
Symbol
Dmel\Rbsn-540-3
Species
D. melanogaster
Name
FlyBase ID
FBal0219036
Feature type
allele
Associated gene
Dmel\Rbsn-5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Morrison et al., 2008)
Mutagen
ethyl methanesulfonate
(Menut et al., 2007)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G3A.

(Morrison et al., 2008)

Nucleotide substitution: M1I.

(Morrison et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:8,160,094..8,160,094 [+]
Nucleotide change:

G8160094A

Reported nucleotide change:

G?A

Amino acid change:

M1I | Rbsn-5-PA

Reported amino acid change:

M1I

(Morrison et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rbsn-540-3 mutant cells display seamless tracheal tube cysts and disorganized tube termini. They also show reduced terminal branching.

      (Schottenfeld-Roames et al., 2014)

      Homozygous and Rbsn40-3/Df(2L)Exel7034 animals die before the second larval instar.

      Homozygous eye discs consist of rounded and dramatically disorganised masses of cells.

      Oocytes derived from homozygous germline clones lack yolk granules.

      (Morrison et al., 2008)

      Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation accompanied by upregulated actin polymerisation and overgrowth.

      (Menut et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Rbsn-540-3/MENE(2L)-C[+], Scer\GAL4en-e16E, Vps45RNAi.UAS.WIZ has visible phenotype

      (Morrison et al., 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Rbsn-540-3 is a suppressor | partially of wing vein L5 phenotype of Df(3L)ru-22/rhove-1

      (Tjota et al., 2011)

      Rbsn-540-3 is a suppressor of wing vein L5 phenotype of rhove-1

      (Tjota et al., 2011)
      Other
      Statement
      Reference

      Rbsn-540-3/MENE(2L)-C[+], Scer\GAL4en-e16E, Vps45RNAi.UAS.WIZ has wing vein | ectopic phenotype

      (Morrison et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Rbsn-540-3 heterozygous background leads to just under 40% suppression of the L5 wing vein defect in both rhove-1/Df(3L)ru-22 kst1 and rhove-1/rhove-1 kst1 flies.

      (Tjota et al., 2011)

      Expression of Vps45dsRNA.Scer\UAS.WIZ under the control of Scer\GAL4en-e16E in a Rbsn40-3/+ background results in ectopic vein formation across the posterior cross vein in 64% of wings.

      (Morrison et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      MENE (2L)-C40-3
      (Menut et al., 2007)
      MENE(2L)-C40-3
      (Morrison et al., 2008)
      Rbsn-540-3
      Rbsn40-3
      rbsn40-3
      (Morrison et al., 2008)
      Name Synonyms
      Rabenosyn40-3
      (Tjota et al., 2011)
      Secondary FlyBase IDs
        References (4)