FB2026_02 , released June 18, 2026
Allele: Dmel\Vps45GG11
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General Information
Symbol
Dmel\Vps45GG11
Species
D. melanogaster
Name
FlyBase ID
FBal0219040
Feature type
allele
Associated gene
Dmel\Vps45
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Morrison et al., 2008)
Mutagen
ethyl methanesulfonate
(Morrison et al., 2008, Menut et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: V219Q.

(Morrison et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,564,795..9,564,795 [+]
Nucleotide change:

T9564795A

Amino acid change:

V219E | Vps45-PA

Reported amino acid change:

V219Q

Comment:

Reported as a conversion from Val219 to Gln (which would require changes to two nucleotides) but suspected to be a typo and mapped as a Val219 to Glu, (which requires a single nucleotide substitution). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Morrison et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae die before the third instar.

      (Morrison et al., 2008)

      Mutant eye discs (generated using the eyFLP-cell lethal system) show epithelial disorganisation accompanied by upregulated actin polymerisation and overgrowth.

      (Menut et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      MENE (3R)-CGG11
      (Menut et al., 2007)
      MENE(3R)-BGG-11
      (Morrison et al., 2008)
      MENE(3R)-BGG11
      (Morrison et al., 2008)
      MENE(3R)-CGG11
      Vps45GG11
      (de Vreede et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)