FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Stam2L2896
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General Information
Symbol
Dmel\Stam2L2896
Species
D. melanogaster
Name
FlyBase ID
FBal0219181
Feature type
allele
Associated gene
Dmel\Stam
Associated Insertion(s)
Carried in Construct
Also Known As
stam2896
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chanut-Delalande et al., 2007)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C16T.

(Chanut-Delalande et al., 2007)

Amino acid replacement: A505T.

(Chanut-Delalande et al., 2007)

Nucleotide substitution: G1513A.

(Chanut-Delalande et al., 2007)

Amino acid replacement: Q6term.

(Chanut-Delalande et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:10,860,898..10,860,898 [+]
Nucleotide change:

G10860898A

Reported nucleotide change:

G1513A

Amino acid change:

A505T | Stam-PA

Reported amino acid change:

A505T

(Chanut-Delalande et al., 2007)
point_mutation
2L:10,858,850..10,858,850 [+]
Nucleotide change:

C10858850T

Reported nucleotide change:

C16T

Amino acid change:

Q6term | Stam-PA

Reported amino acid change:

Q6term

(Chanut-Delalande et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mushroom body gamma neuron clones show normal axon pruning.

      (Issman-Zecharya and Schuldiner, 2014)

      Stam2L2896 follicular epithelium clones display normal epithelial morphology.

      There is no detectable phenotype in Stam2L2896 mosaic eye imaginal discs or imaginal discs consisting predominantly of mutant cells.

      Eye discs consisting predominantly of cells mutant for Stam2L2896 progress to form adult eyes. These are smaller than wild-type and have a rough appearance but contain some mutant photoreceptors. The scarcity of mutant adult photoreceptors might be due to cell death, as apoptotic cells are seen these mutants.

      (Tognon et al., 2014)

      Homozygous clones show defects in tracheal cell migration during morphogenesis of the dorsal air sac primordium; less than 40% of clones reach the distal tip of the primordium.

      (Chanut-Delalande et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      HrsD28/HrsD28 Stam2L2896/Stam2L2896 MARCM ddaC double mutant clones show dendrite pruning similar to wild type at 18hr APF.

      (Loncle et al., 2015)

      HrsD28 Stam2L2896 double homozygous mushroom body gamma neuron clones show defects in axon pruning.

      (Issman-Zecharya and Schuldiner, 2014)

      HrsD28 Stam2L2896 follicular epithelium clones display normal epithelial morphology.

      HrsD28 Stam2L2896 l(2)gl4 follicular epithelium clones display normal epithelial morphology.

      (Tognon et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      2L 2896
      (Chanut-Delalande et al., 2007)
      Stam2L-2896
      (Loncle et al., 2015)
      Stam2L2896
      (Pannen et al., 2020, Mukherjee et al., 2016, Tognon et al., 2014)
      stam2896
      (Sheng et al., 2016, Issman-Zecharya and Schuldiner, 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)