FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pabp26
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General Information
Symbol
Dmel\Pabp26
Species
D. melanogaster
Name
FlyBase ID
FBal0219383
Feature type
allele
Associated gene
Dmel\Pabp2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Benoit et al., 2005)
Mutagen
P-element activity
(Benoit et al., 2005)
Progenitor genotype
Pabp2EP2264
(Benoit et al., 2005)
Cytology
Description

A small internal deletion of P{EP}Pabp2EP2264.

(Benoit et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Development of many of the egg chambers in Pabp26 homozygous females is arrested at stage 8. These females do lay some eggs, but over 90% of these do not hatch and about half have polarity defects or a thin chorion. Early stage defects in these embryos suggest cell-cycle irregularities: nuclei of various sizes are present; nuclei are distributed unevenly; cellularization is sometimes defective. A similar range of phenotypes is seen in embryos from Pabp26 homozygous germ-line clones.

      (Benoit et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The maternal effect embryonic lethality due to Pabp26 is rescued when the mothers also carry Pabp2I61S.g.

      (Benoit et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Pabp26 is partially rescued by Pabp2I61S.g

      (Benoit et al., 2005)
      Comments

      The maternal effect embryonic lethality due to Pabp26 is rescued when the mothers also carry Pabp2I61S.g.

      (Benoit et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pabp26
      (Benoit et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)