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General Information
Symbol
Dmel\AkhRnull
Species
D. melanogaster
Name
FlyBase ID
FBal0220479
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Approximate boundaries of the GRHRnull deletion, which was reported as a deletion of the GRHR coding sequence and about 150 bp beyond GRHR, resulting from imprecise excsion of P{EPgy2}GRHREY11371. Approximately 400 bp of P element sequence remain.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EPgy2}GRHREY11371 insertion, resulting in a deletion that removes the entire GRHR coding sequence. An approximately 450bp remnant of the insertion remains.

Insertion components
P{?EPgy2}AkhRnull
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

AkhRnull mutant adults have a significantly lower firing rate of interoceptive SEZ neurons than controls under starved, but not fed, conditions; unlike in controls, firing rate does not significantly increase during starvation.

1 week old GRHRnull flies have markedly larger cells in the fat body than control flies.

GRHRnull flies show no gross difference in food intake compared to controls under normal feeding conditions. After 18-24 hours starvation, GRHRnull flies show reduced food intake compared to controls.

Tissue size (wing, mesothorax and foreleg femur length) and cell size (wing cell size) in GRHRnull flies is indistinguishable from that of controls.

GRHRnull flies are markedly starvation resistant compared to controls, surviving for 3-4 days under starvation conditions and remaining fertile even after 48 hours of starvation.

Locomotor activity and circadian rhythm is normal in GRHRnull flies under normal feeding conditions. In addition, GRHRnull flies show no significant difference in locomotor activity compared to control flies during the first 24 hours of starvation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
AkhRnull
GRHRnull
Name Synonyms
Secondary FlyBase IDs
    References (2)