FlyBase Allele Report: Dmel\LIMK1[JF02063]

General Information

Symbol

Dmel\LIMK1^JF02063

Species

D. melanogaster

Name

FlyBase ID

FBal0220554

Feature type

allele

Associated gene

Dmel\LIMK1

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02063}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02063}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02063

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4^Act.PU

(Stephan et al., 2012)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PLu

(Miller et al., 2011)

Phenotype Manifest In

adult olfactory receptor neuron Or59c | somatic clone, with Scer\GAL4^Act.PU

(Stephan et al., 2012)

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^elav.PLu

(Miller et al., 2011)

Detailed Description

Statement

Reference

Expression of LIMK1^JF02063 under the control of Scer\GAL4^Act.PU in olfactory receptor neuron (ORN) clones results in Or59c-expressing ORNs mistargeting in only 10% of cases.

(Stephan et al., 2012)

ISNb axons displaying targeting and defasciculation errors in embryos expressing LIMK1^JF02063 under the control of Scer\GAL4^elav.PLu.

(Miller et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

LIMK1^JF02063, Scer\GAL4^ey.PU is a suppressor | partially of increased size | adult stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

LIMK1^JF02063, Scer\GAL4^ey.PU is a suppressor | partially of visible | adult stage phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

Scer\GAL4^Act.PU/LIMK1^JF02063 is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of psidin¹

(Stephan et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

LIMK1^JF02063, Scer\GAL4^ey.PU is a suppressor | partially of adult head phenotype of BacA\p35^UAS.cUa, Scer\GAL4^ey.PU, hid^UAS.cUa

(Farrell et al., 2022)

Scer\GAL4^Act.PU/LIMK1^JF02063 is a suppressor of adult olfactory receptor neuron Or59c | somatic clone phenotype of psidin¹

(Stephan et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of LIMK1^JF02063 under the control of Scer\GAL4^Act.PU significantly rescues the axon mistargeting phenotype seen in Or59c-expressing psidin¹ olfactory receptor neuron clones.

(Stephan et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26294

y¹ v¹; P{TRiP.JF02063}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

LIMK1^JF02063

LIMK1^JF2063

(Miller et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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