FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)gl3A.UASp
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General Information
Symbol
Dmel\l(2)gl3A.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0220824
Feature type
allele
Associated gene
Dmel\l(2)gl
Associated Insertion(s)
Carried in Construct
P{UASp-l(2)gl.3A}
Key Links
Transgenic product class
missense_variant
(Tian and Deng, 2008)
polypeptide_post_translational_processing_variant
(Tian and Deng, 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tian and Deng, 2008)
polypeptide_post_translational_processing_variant
(Tian and Deng, 2008)
Mutagen
in vitro construct
(Tian and Deng, 2008)
Progenitor genotype
Carried in construct
P{UASp-l(2)gl.3A}
Cytology
Description

UASp regulatory sequences drive expression of a mutated form of l(2)gl in which all three aPKC phosphorylation sites have been mutated to alanine.

(Tian and Deng, 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
l(2)gl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The oocyte nucleus is mislocalised to the posterior of the oocyte in egg chambers of females expressing l(2)gl3A.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

      (Tian and Deng, 2009)

      Females expressing l(2)gl3A.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 have a high density of microtubules around the cortex or in the central or lateral part of the oocyte. The oocyte nucleus is mislocalised in some of these egg chambers.

      (Tian and Deng, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of l(2)gl3A.Scer\UAS.P\T under the control of Scer\GAL4elav-C155 suppresses the neuroblast overgrowth phenotype found in Zif1L15 mutant clones.

      (Chang et al., 2010)

      The oocyte nucleus is mislocalised to the centre of the oocyte in 43% of egg chambers of females co-expressing par-1N1S.Scer\UAS.P\T.T:Avic\GFP-m6 and l(2)gl3A.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

      (Tian and Deng, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)gl3A.Scer\UAS.P\T
      l(2)gl3A.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (3)