FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Zif1L15
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General Information
Symbol
Dmel\Zif1L15
Species
D. melanogaster
Name
FlyBase ID
FBal0260628
Feature type
allele
Associated gene
Dmel\Zif
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chang et al., 2010)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q110term.

(Chang et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,457,673..6,457,673 [+]
Nucleotide change:

C6457673T

Amino acid change:

Q109term | Zif-PA; Q109term | Zif-PB; Q109term | Zif-PC

Reported amino acid change:

Q110term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The mutation was mapped to residue 109 in the reference sequence even though residue 110 (the reported location) is also Gln because the locations of the other two mutations mapped from FBrf0212286 differed by one in the reference sequence relative to the reported position.

(Chang et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Zif1L15/Zif1L15 somatic clones of terminal tracheal cells are reduced in size, with little or no branching, lack cell polarity and form discontinuous tubes in third instar larvae. Heterozygous neighboring stalk cells show compensatory branching.

      (Burguete et al., 2019)

      Zif1L15 mutant clones exhibit supernumerary neuroblast-like cells (labeled by mira).

      Zif1L15 mutant type-I neuroblast clones exhibit an overgrowth of neuroblast formation. This occurs at the expense of neuron formation, as very few elav-positive neurons are observed in these clones. Type-II Zif1L15 clones exhibit an increased number of neuroblasts.

      (Chang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The neuroblast overgrowth phenotype seen in Zif1L15 mutant clones is significantly suppressed in a aPKCk06403 heterozygous background.

      Overexpression of l(2)gl3A.Scer\UAS.P\T under the control of Scer\GAL4elav-C155 suppresses the neuroblast overgrowth phenotype found in Zif1L15 mutant clones.

      (Chang et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Zif1L15
      (Burguete et al., 2019, Chang et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)