FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bun200B
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General Information
Symbol
Dmel\bun200B
Species
D. melanogaster
Name
FlyBase ID
FBal0221070
Feature type
allele
Associated gene
Dmel\bun
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Gluderer et al., 2008)
Progenitor genotype
bunGE12921
(Gluderer et al., 2008)
Cytology
Description

Imprecise excision of the insertion in bunGE12921, resulting in a deletion that affects all bun isoforms; the deletion starts 29bp upstream of the bun common exon and extends for 641bp, removing the splice acceptor site of the common exon.

(Gluderer et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:12,457,612..12,458,252 [-]
Comment:

Imprecise excision of P{EP}bunGE12921, resulting in a deletion that affects all bun isoforms; the deletion starts 29bp upstream of the bun common exon and extends for 641bp.

(Gluderer et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      bun200B/bun200B mutant intestinal stem cell clones have significantly fewer cells and a smaller size than control clones.

      (Nie et al., 2015)

      Homozygotes die mostly at the larval stage.

      Mosaic flies with eye and head capsules largely homozygous for bun200B (generated using the eyFLP/FRT technique) have small heads ("pinhead" phenotype). The number of ommatidia in these mosaics is significantly reduced compared to wild type and the mutant photoreceptors are smaller than the surrounding heterozygous cells.

      bun200B/Df(2L)Exel6033 larvae are massively reduced in size compared to controls, reach the third larval instar with a delay of 24 hours and die within a few days of having reached this stage.

      (Gluderer et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      bun200B/bun200B is a suppressor | somatic clone of adult midgut | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Tub.PU

      (Nie et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The presence of bun200B/bun200B suppresses the increased cell number seen in midgut clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4tub.PU.

      (Nie et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      bun200B is rescued by bunUAS.GFP

      (Gluderer et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      200B
      (Gluderer et al., 2008)
      bun200B
      (Nie et al., 2015, Gluderer et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)