FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mnt1
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General Information
Symbol
Dmel\Mnt1
Species
D. melanogaster
Name
FlyBase ID
FBal0221201
Feature type
allele
Associated gene
Dmel\Mnt
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Loo et al., 2005)
Mutagen
Delta2-3 transposase
(Loo et al., 2005)
Progenitor genotype
P{EP}EP1559
(Loo et al., 2005)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion which removes all exons contributing to the open reading frame of the Mnt isoform that contains both the SID and bHLHZ domains.

(Loo et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant flies show an increase n ommatidial size compared to controls.

      (Steiger et al., 2008)

      The survival of homozygous and wild-type larvae under starvation conditions is not significantly different.

      (Loo et al., 2005)

      Homozygous embryos show no significant difference in hatching rates compared to controls. No defects are seen in larval molting, pupation or eclosion in homozygotes.

      Mutant adult males are 20% heavier than wild-type controls. Mutant males have 18% fewer wing trichomes in a defined area of the adult wing, indicative of an increase in cell size.

      Mutant females show a significant reduction in adult life span compared to controls. There is also a reduction in the maximal life expectancy (90% mortality) compared to controls.

      (Loo et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mnt1 is a suppressor of lethal | recessive phenotype of Myc4

      (Steiger et al., 2008)

      Mnt1 is a suppressor of decreased body size | larval stage phenotype of Myc4

      (Steiger et al., 2008)
      Other
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Mnt1 is a non-suppressor of ommatidium phenotype of MycUAS.cZa, Scer\GAL4GMR.PF

      (Steiger et al., 2008)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ability of dmΔMB2.αTub84B.T:HA1 to rescue the lethality of dm4 is increased if the flies are also mutant for Mnt1.

      (Schwinkendorf and Gallant, 2009)

      dm4 ; Mnt1 double mutant clones in the fat body contain tiny cells that have minuscule nuclei.

      The eye phenotypes (apoptosis and increased ommatidial size) caused by expression of three copies of dmScer\UAS.cZa under the control of Scer\GAL4GMR.PF are not qualitatively altered by Mnt1/Y.

      (Steiger et al., 2008)

      dm4 Mnt1 and dm4 Mnt1 Max1 larvae grow better and survive to a greater extent than dm4 single mutant larvae.

      dm4 Mnt1 larval fat body and salivary gland cells are severely stunted compared to controls.

      (Steiger et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mnt1
      (Demontis et al., 2014, Steiger et al., 2008, Steiger et al., 2008)
      dmnt1
      (Loo et al., 2005, Loo et al., 2005)
      mnt1
      (Schwinkendorf and Gallant, 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)