FlyBase Allele Report: Dmel\moi[M12]

General Information

Symbol

Dmel\moi^M12

Species

D. melanogaster

Name

FlyBase ID

FBal0221229

Feature type

allele

Associated gene

Dmel\moi

Associated Insertion(s)

P{?PTT-GB}moi^M12

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Raffa et al., 2009)

Mutagen

P-element activity

(Raffa et al., 2009)

Progenitor genotype

P{PTT-GB}moi^CB02140

(Raffa et al., 2009)

Associated Insertion(s)

P{?PTT-GB}moi^M12

Cytology

Description

Imprecise excision of the progenitor insertion. 261bp of the original insertion, plus a 9bp duplication of the insertion site, remain. The inserted fragment contains a stop codon, leading to a truncation of the moi protein.

(Raffa et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | larval stage

(Cenci et al., 2015)

Phenotype Manifest In

chromosome, telomeric region

(Raffa et al., 2009)

chromosome | larval stage

(Cenci et al., 2015)

larval neuroblast

(Cenci et al., 2015)

Detailed Description

Statement

Reference

In moi^M12 homozygous larvae, neuroblasts exhibit telomeric fusions, particularly in autosomes.

(Cenci et al., 2015)

Mitotic cells from the brains of homozygous larvae show frequent telomere fusions.

(Raffa et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

moi^M12 is rescued by moi^R1.Tub

(Raffa et al., 2009)

moi^M12 is rescued by moi^R2.Tub

(Raffa et al., 2009)

moi^M12 is rescued by moi^R3.Tub

(Raffa et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

The lesion in the moi^M12 mutant is in the upstream ORF (moi) of a dicistronic locus that encodes moi (upstream ORF) and tatl (downstream ORF). The telomere fusion and lethal phenotypes of moi^M12 homozygotes are fully rescued by a transgene containing only the moi ORF, indicating that the lesion appears to affect only moi and not tatl.

(Raffa et al., 2009)

Comments

Allelic series (with respect to severity of telomere fusion phenotype): moi¹ > moi^CB02140 = moi^M12 > moi^S096713.

(Raffa et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

moi^M12

(Cenci et al., 2015, Raffa et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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