Gene model reviewed during 5.52
Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\moi using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\moi in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: tlu CG42350
Source for merge of: moi tlu
FlyBase curator comment: In 2005, Komonyi et al. (FBrf0184045) referred to the original single CG31241 annotation, which produces a dicistronic transcript, as 'dtl'. In February 2009, Raffa et al. (FBrf0206682) characterized the upstream ORF, referring to it as 'moi' (which now has its own annotation ID of CG42350), and retained the 'dtl' designation for the downstream ORF (which now has its own annotation ID of CG44890). In March 2009, Komonyi et al. (FBrf0207599) also characterized the upstream ORF (CG42350) but retained the 'dtl'/'DTL' designation for it, while referring to the downstream ORF (CG44890) as 'TGS1'. In an attempt to reduce confusion, the upstream ORF (CG42350) is named 'moi' in FlyBase (according to FBrf0206682) and the downstream ORF (CG44890) is named 'Tsg1' in FlyBase (according to FBrf0207599), with 'dtl' being retained as a synonym of both.
One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG42350 (FBgn0259681), CG31241 (FBgn0051241).
The gene is named "modigliani" after the name of an Italian train, after the mutant phenotype of multiple telomeric associations in the same metaphase spread, which often results in multicentric linear chromosomes that resemble little "trains" of chromosomes.
Named "modigliani" after an Italian train, as the multicentric chromosomes observed in mutants resemble little trains of chromosomes.