l(3)S096713
a novel protein enriched at telomeres that is required to prevent telomeric fusion - forms a protein complex that is functionally analogous to shelterin
Please see the JBrowse view of Dmel\moi for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.
There is only one protein coding transcript and one polypeptide associated with this gene
Probably homodimerizes (PubMed:15684427). Component of the MTV complex, composed of moi/modigliani, tea and ver/verrocchio (PubMed:27835648). Interacts with ver/verrochio and tea (via C-terminus); the interactions are direct and require fully intact moi/modigliani and ver/verrocchio (PubMed:20679394, PubMed:27835648). The MTV complex is recruited to telomeres by the HipHop-HOAP complex, consisting of HipHop, cav/HOAP and Su(var)205/HP1 to form the terminin telomere-capping complex (PubMed:19181850, PubMed:20679394, PubMed:27835648). Interacts with cav/HOAP and Su(var)205/HP1; the interactions are direct (PubMed:19181850). Probably interacts with peo (via N-terminus and UBC domain) (PubMed:26110638).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\moi using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as embryonic central brain mushroom body
JBrowse - Visual display of RNA-Seq signals
View Dmel\moi in JBrowse3-62
3-61.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutant larvae have increased frequencies of telomeric fusions in brain cells.
Source for merge of: moi tlu
One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG42350 (FBgn0259681), CG31241 (FBgn0051241).
Source for identity of: tlu CG42350
FlyBase curator comment: In 2005, Komonyi et al. (FBrf0184045) referred to the original single CG31241 annotation, which produces a dicistronic transcript, as 'dtl'. In February 2009, Raffa et al. (FBrf0206682) characterized the upstream ORF, referring to it as 'moi' (which now has its own annotation ID of CG42350), and retained the 'dtl' designation for the downstream ORF (which now has its own annotation ID of CG44890). In March 2009, Komonyi et al. (FBrf0207599) also characterized the upstream ORF (CG42350) but retained the 'dtl'/'DTL' designation for it, while referring to the downstream ORF (CG44890) as 'TGS1'. In an attempt to reduce confusion, the upstream ORF (CG42350) is named 'moi' in FlyBase (according to FBrf0206682) and the downstream ORF (CG44890) is named 'Tsg1' in FlyBase (according to FBrf0207599), with 'dtl' being retained as a synonym of both.
Named 'modigliani' after the name of an Italian train, because mutants exhibit multicentric linear chromosomes that resemble little 'trains' of chromosomes.
