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General Information
Symbol
Dmel\Mnt2
Species
D. melanogaster
Name
FlyBase ID
FBal0221793
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion of Mnt sequences. The deletion removes the exon containing the translational start codons of both the Mnt isoform that contains both the SID and bHLHZ domains and of the Mnt ΔZIP isoform, but does not extend to the exon containing the translational start codon of the Mnt ΔZIP isoform.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies show an increase n ommatidial size compared to controls.

Homozygous embryos show no significant difference in hatching rates compared to controls. No defects are seen in larval molting, pupation or eclosion in homozygotes.

Mutant adult males are 12% heavier than wild-type controls. Mutant males have 10 fewer wing trichomes in a defined area of the adult wing, indicative of an increase in cell size.

Mutant females show a significant reduction in adult life span compared to controls. There is also a reduction in the maximal life expectancy (90% mortality) compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The eye phenotypes (apoptosis and increased ommatidial size) caused by expression of three copies of dmScer\UAS.cZa under the control of Scer\GAL4GMR.PF are not qualitatively altered by Mnt2/Y.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)