FB2026_02 , released June 18, 2026
Allele: Dmel\RtcaNP5057
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General Information
Symbol
Dmel\RtcaNP5057
Species
D. melanogaster
Name
FlyBase ID
FBal0222336
Feature type
allele
Associated gene
Dmel\Rtca
Associated Insertion(s)
P{GawB}RtcaNP5057
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Song et al., 2015)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}RtcaNP5057
    Cytology
    Description

    Insertion in the 5'UTR which results in reduced transcript expression.

    (Song et al., 2015)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        After axons are severed, RtcaNP5057/RtcaNP5057 larvae show increased axon regrowth (significantly increased regeneration percentage, terminal branching, and commissure regrowth) and RtcaNP5057/Df(1)BSC718 larvae show increased regeneration percentage and terminal branching compared to wild type.

        (Song et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Enhanced by
        Statement
        Reference

        RtcaNP5057 has increased cell growth rate | second instar larval stage | conditional phenotype, non-enhanceable by PtenMGH6

        (Song et al., 2015)
        Suppressed by
        Statement
        Reference

        RtcaNP5057 has increased cell growth rate | second instar larval stage | conditional phenotype, suppressible by Archeasec01013

        (Song et al., 2015)

        RtcaNP5057 has increased cell growth rate | second instar larval stage | conditional phenotype, suppressible by Xbp1k13803

        (Song et al., 2015)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Regeneration is not enhanced in RtcaNP5057;PtenMGH6 double mutants.

        Enhanced axon regeneration seen in RtcaNP5057/RtcaNP5057 larvae is abolished in RtcaNP5057;Archeasec01013 double mutants.

        Enhanced axon regeneration is dampened in RtcaNP5057;Xbp1k13803 double mutants.

        (Song et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG4061NP5057
        RtcaNP5057
        (Wang et al., 2025, Vargas et al., 2020, Song et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)