FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PtenMGH6
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General Information
Symbol
Dmel\PtenMGH6
Species
D. melanogaster
Name
FlyBase ID
FBal0276877
Feature type
allele
Associated gene
Dmel\Pten
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        After axons are severed, PtenMGH6/PtenMGH6 larvae have increased axon regrowth compared to wild type.

        (Song et al., 2015)

        Axon regeneration of class IV da neurons in the ventral nerve cord (after axon severing at the commissure junction at 48 hours after egg laying) is dramatically stimulated in mutant larvae compared to wild type (70.6% of the mutant segments containing a severed axon show regeneration compared to 25% in wild type). The mutant severed axons show increased sprouting compared to controls, and many of them regrow beyond the lesion site, show extensive terminal branching once they regrow into commissures and bridge the severed commissure segments.

        (Song et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        PtenMGH6 has increased cell growth rate | second instar larval stage | conditional phenotype, suppressible by RtcaUAS.cSa/Scer\GAL4ppk.PU

        (Song et al., 2015)
        NOT Enhancer of
        Statement
        Reference

        PtenMGH6 is a non-enhancer of increased cell growth rate | second instar larval stage | conditional phenotype of RtcaNP5057

        (Song et al., 2015)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Overexpression of RtcaScer\UAS.cSa driven by Scer\GAL4ppk.PU abolishes enhancement of axon regeneration seen in PtenMGH6/PtenMGH6 larvae.

        Regeneration is not enhanced in RtcaNP5057;PtenMGH6 double mutants.

        (Song et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        PtenMGH6
        (Song et al., 2015, Song et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)