FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CIAPIN1NP5152
Open Close
General Information
Symbol
Dmel\CIAPIN1NP5152
Species
D. melanogaster
Name
FlyBase ID
FBal0222340
Feature type
allele
Associated gene
Dmel\CIAPIN1
Associated Insertion(s)
P{GawB}CIAPIN1NP5152
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}CIAPIN1NP5152
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        CIAPIN12/CIAPIN1NP5152 females have rudimentary ovaries, which contain no egg chambers beyond stage 8 of development. A loss of follicle cells is seen, such that follicle cell tissue fails to cover the entire egg chamber. A significant reduction in the number of follicle cells per egg chamber is seen by stage 4. An increased level of follicle cell apoptosis is seen compared to wild type, with apoptosis being detected as early as stage 2. Follicle cell replication (as assayed by BrdU incorporation) appear normal, but there is a marked decrease in mitotic index of the follicle cells compared to wild type, with more than 90% of stage 2-4 egg chambers having a mitotic index of zero. All phases of mitosis are readily identified in the mutant follicle cells, with no significant difference in the fraction of cells in each phase compared to wild type.

        (Marzuk et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        CIAPIN12/CIAPIN1NP5152 is rescued by Scer\GAL4Act.PU/CIAPIN1UASp.cMa

        (Marzuk et al., 2013)

        CIAPIN1NP5152 is rescued by Scer\GAL4Act.PU/CIAPIN1UASp.cMa

        (Marzuk et al., 2013)
        Not rescued by

        CIAPIN12/CIAPIN1NP5152 is not rescued by Scer\GAL4VP16.nanos.UTR/CIAPIN1UASp.cMa

        (Marzuk et al., 2013)
        Comments

        Expression of CIAPIN1Scer\UAS.P\T.cMa under the control of Scer\GAL4Act.PU rescues the lethality of CIAPIN1NP5152 homozygotes, and rescues the sterility of CIAPIN12/CIAPIN1NP5152 males and females.

        Expression of CIAPIN1Scer\UAS.P\T.cMa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fails to rescue ovarian development in CIAPIN12/CIAPIN1NP5152 females.

        (Marzuk et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Excision of the insertion reverts the lethal phenotype.

        (Marzuk et al., 2013)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CIAPIN1NP5152
        D-CIAPIN1NP
        (Marzuk et al., 2013)
        l(2)35BgNP5152
        (Marzuk et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)